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TLX3

From Wikipedia, the free encyclopedia
TLX3
Identifiers
AliasesTLX3, HOX11L2, RNX, T-cell leukemia homeobox 3, T cell leukemia homeobox 3
External IDsOMIM: 604640; MGI: 1351209; HomoloGene: 23181; GeneCards: TLX3; OMA:TLX3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021025

NM_019916

RefSeq (protein)

NP_066305

NP_064300

Location (UCSC)Chr 5: 171.31 – 171.31 MbChr 11: 33.15 – 33.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.[5][6][7]

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993).[supplied by OMIM][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164438Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040610Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lee-Kirsch MA, Engel K, Paditz E, Rosen-Wolff A, Lee YA, Gahr M (Jul 2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping". Cytogenet Cell Genet. 92 (3–4): 358. doi:10.1159/000056933. PMID 11435718. S2CID 85323468.
  6. ^ Cinti R, Fava M, Sancandi M, Matera I, Ravazzolo R, Ceccherini I (Jul 2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization". Cytogenet Cell Genet. 92 (3–4): 354–5. doi:10.1159/000056931. PMID 11435716. S2CID 35224759.
  7. ^ a b "Entrez Gene: TLX3 T-cell leukemia homeobox 3".

Further reading

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