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RFX3

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RFX3
Identifiers
AliasesRFX3, regulatory factor X3
External IDsOMIM: 601337; MGI: 106582; HomoloGene: 7917; GeneCards: RFX3; OMA:RFX3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282116
NM_001282117
NM_002919
NM_134428
NM_001377999

NM_001166414
NM_011265
NM_001360357
NM_001360358

RefSeq (protein)

NP_001269045
NP_001269046
NP_002910
NP_602304
NP_001364928

NP_001159886
NP_035395
NP_001347286
NP_001347287

Location (UCSC)Chr 9: 3.22 – 3.53 MbChr 19: 27.74 – 27.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.[5][6]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080298Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040929Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B (Feb 1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol Cell Biol. 14 (2): 1230–44. doi:10.1128/mcb.14.2.1230. PMC 358479. PMID 8289803.
  6. ^ a b "Entrez Gene: RFX3 regulatory factor X, 3 (influences HLA class II expression)".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.