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SOX13

From Wikipedia, the free encyclopedia
SOX13
Identifiers
AliasesSOX13, ICA12, Sox-13, SRY-box 13, SRY-box transcription factor 13
External IDsOMIM: 604748; MGI: 98361; HomoloGene: 4159; GeneCards: SOX13; OMA:SOX13 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005686

NM_011439

RefSeq (protein)

NP_005677

NP_035569

Location (UCSC)Chr 1: 204.07 – 204.13 MbChr 1: 133.31 – 133.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor SOX-13 is a protein that in humans is encoded by the SOX13 gene.[5][6]

Function

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This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.[6]

In melanocytic cells SOX13 gene expression may be regulated by MITF.[7]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143842Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070643Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H (Apr 1999). "The Sox-13 gene: structure, promoter characterization, and chromosomal localization". Genomics. 57 (2): 301–5. doi:10.1006/geno.1999.5779. PMID 10198172.
  6. ^ a b "Entrez Gene: SOX13 SRY (sex determining region Y)-box 13".
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.