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PKNOX1

From Wikipedia, the free encyclopedia
PKNOX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPKNOX1, PREP1, pkonx1c, PBX/knotted 1 homeobox 1
External IDsOMIM: 602100; MGI: 1201409; HomoloGene: 3363; GeneCards: PKNOX1; OMA:PKNOX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286258
NM_004571
NM_001320694
NM_197976

NM_016670

RefSeq (protein)

NP_057879

Location (UCSC)Chr 21: 42.97 – 43.03 MbChr 17: 31.78 – 31.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PBX/Knotted 1 Homeobox 1 (PKNOX1) is a protein that in humans is encoded by the PKNOX1 gene.[5][6]

An important paralog of this gene is PKNOX2.

Function

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PKNOX1 belongs to the three amino acid loop extension (TALE) class of homeodomain transcription factors that form transcriptionally active complexes involved in development and organogenesis. PKNOX1 is essential for embryogenesis, but it can also act as a tumor suppressor in adulthood.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160199Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006705Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Berthelsen J, Viggiano L, Schulz H, Ferretti E, Consalez GG, Rocchi M, Blasi F (January 1998). "PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C". Genomics. 47 (2): 323–4. doi:10.1006/geno.1997.5086. PMID 9479508.
  6. ^ "Entrez Gene: PKNOX1 PBX/knotted 1 homeobox 1". Archived from the original on 2010-12-05. Retrieved 2017-09-07.
  7. ^ Purushothaman D, Blasi F (2018). "The genetics and the molecular functions of the PREP1 homeodomain transcription factor". The International Journal of Developmental Biology. 62 (11–12): 819–825. doi:10.1387/ijdb.180238fb. PMID 30604851.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.