Correspondence |
Featured
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Comment |
AI can help to tailor drugs for Africa — but Africans should lead the way
Computational models that require very little data could transform biomedical and drug development research in Africa, as long as infrastructure, trained staff and secure databases are available.
- Gemma Turon
- , Mathew Njoroge
- & Kelly Chibale
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Technology Feature |
‘Without these tools, I’d be lost’: how generative AI aids in accessibility
A rush to place barriers around the use of artificial intelligence in academia could disproportionately affect those who stand to benefit most.
- Amanda Heidt
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Career Column |
Three ways ChatGPT helps me in my academic writing
Generative AI can be a valuable aid in writing, editing and peer review – if you use it responsibly, says Dritjon Gruda.
- Dritjon Gruda
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Career Feature |
Ready or not, AI is coming to science education — and students have opinions
As educators debate whether it’s even possible to use AI safely in research and education, students are taking a role in shaping its responsible use.
- Sarah Wells
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Research Briefing |
Artificial intelligence can provide accurate forecasts of extreme floods at global scale
Anthropogenic climate change is accelerating the hydrological cycle, causing an increase in the risk of flood-related disasters. A system that uses artificial intelligence allows the creation of reliable, global river flood forecasts, even in places where accurate local data are not available.
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Article
| Open AccessImmune microniches shape intestinal Treg function
Studies in mice show that effector T regulatory cells in the gut are most functional in the lamina propria, but this homeostatic niche is disrupted in inflammation, suggesting a spatial mechanism of tolerance to commensal microorganisms.
- Yisu Gu
- , Raquel Bartolomé-Casado
- & Fiona Powrie
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Article
| Open AccessThe complex polyploid genome architecture of sugarcane
We build a polyploid reference genome for hybrid sugarcane cultivar R570, improving on its current ‘mosaic monoploid’ representation, enabling fine-grain description of genome architecture and the exploration of candidate genes underlying the Bru1 brown rust resistance locus.
- A. L. Healey
- , O. Garsmeur
- & A. D’Hont
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Article
| Open AccessSingle-cell multiplex chromatin and RNA interactions in ageing human brain
We introduce multinucleic acid interaction mapping in single cells (MUSIC), for concurrent profiling of multiplex chromatin interactions, gene expression and RNA–chromatin associations within individual nuclei, as a tool for exploring chromatin architecture and transcription.
- Xingzhao Wen
- , Zhifei Luo
- & Sheng Zhong
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News Feature |
How AI is improving climate forecasts
Researchers are using various machine-learning strategies to speed up climate modelling, reduce its energy costs and hopefully improve accuracy.
- Carissa Wong
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News |
Google AI could soon use a person’s cough to diagnose disease
Machine-learning system trained on millions of human audio clips shows promise for detecting COVID-19 and tuberculosis.
- Mariana Lenharo
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Article
| Open AccessA distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche
A study reveals that Fusobacterium nucleatum subspecies animalis is bifurcated into two distinct clades, and shows that only one of these dominates the colorectal cancer niche, probably through increased colonization of the human gastrointestinal tract.
- Martha Zepeda-Rivera
- , Samuel S. Minot
- & Christopher D. Johnston
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Correspondence |
Three reasons why AI doesn’t model human language
- Johan J. Bolhuis
- , Stephen Crain
- & Andrea Moro
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News |
‘A landmark moment’: scientists use AI to design antibodies from scratch
Modified protein-design tool could make it easier to tackle challenging drug targets — but AI antibodies are still a long way from reaching the clinic.
- Ewen Callaway
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News Feature |
AI image generators often give racist and sexist results: can they be fixed?
Researchers are tracing sources of racial and gender bias in images generated by artificial intelligence, and making efforts to fix them.
- Ananya
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News & Views |
Can lessons from infants solve the problems of data-greedy AI?
Words and images experienced by an infant wearing sensors during their daily life have led to efficient machine learning, pointing to the power of multimodal training signals and to the potentially exploitable statistics of real-life experience.
- Linda B. Smith
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Research Briefing |
‘Bandit’ algorithms help chemists to discover generally applicable conditions for reactions
In organic chemistry, finding conditions that enable a broad range of compounds to undergo a particular type of reaction is highly desirable. However, conventional methods for doing so consume a lot of time and reagents. A machine-learning method has been developed that overcomes these problems.
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Nature Index |
How AI is being used to accelerate clinical trials
From study design to patient recruitment, researchers are investigating ways that technology could speed up the process.
- Matthew Hutson
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Nature Index |
Four change-makers seek impact in medical research
Bringing fresh perspectives to long-standing health challenges, these scientists are using techniques such as big-data analytics and AI to push the field.
- Amy Coombs
- & Sandy Ong
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News |
Chatbot AI makes racist judgements on the basis of dialect
Some large language models harbour hidden biases that cannot be removed using standard methods.
- Elizabeth Gibney
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Article
| Open AccessBlueprinting extendable nanomaterials with standardized protein blocks
A study describes an approach using designed building blocks that are far more regular in geometry than natural proteins to construct modular multicomponent protein assemblies.
- Timothy F. Huddy
- , Yang Hsia
- & David Baker
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Article
| Open AccessSpatially organized cellular communities form the developing human heart
Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of cardiac cell types that form and remodel the human heart.
- Elie N. Farah
- , Robert K. Hu
- & Neil C. Chi
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Correspondence |
Embrace AI to break down barriers in publishing for people who aren’t fluent in English
- Charles Morphy D. Santos
- & João Paulo Gois
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Technology Feature |
No installation required: how WebAssembly is changing scientific computing
Enabling code execution in the web browser, the multilanguage tool is powerful but complicated.
- Jeffrey M. Perkel
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News |
Could AI-designed proteins be weaponized? Scientists lay out safety guidelines
AI tools that can come up with protein structures at the push of a button should be used safely and ethically, say researchers in the field.
- Ewen Callaway
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News Explainer |
AI-generated images and video are here: how could they shape research?
Scientists are already using image-generating models to jazz up papers and presentations. But some say these tools could harm research.
- Carissa Wong
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Editorial |
Why scientists trust AI too much — and what to do about it
Some researchers see superhuman qualities in artificial intelligence. All scientists need to be alert to the risks this creates.
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Article
| Open AccessDecoding chromatin states by proteomic profiling of nucleosome readers
A multidimensional proteomics analysis of the interactions between around 2,000 nuclear proteins and over 80 modified dinucleosomes representing promoter, enhancer and heterochromatin states provides insights into how chromatin states are decoded by chromatin readers.
- Saulius Lukauskas
- , Andrey Tvardovskiy
- & Till Bartke
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World View |
Here’s what many digital tools for chronic pain are doing wrong
To address the chronic-pain crisis, digital health technologies must break out of their silos and become integrative and holistic.
- Benjamin Lipp
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News Explainer |
Is ChatGPT making scientists hyper-productive? The highs and lows of using AI
Large language models are transforming scientific writing and publishing. But the productivity boost that these tools bring could have a downside.
- McKenzie Prillaman
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Article
| Open AccessAutomated model building and protein identification in cryo-EM maps
ModelAngelo builds atomic models and identifies proteins with unknown sequences in cryo-EM maps.
- Kiarash Jamali
- , Lukas Käll
- & Sjors H. W. Scheres
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Article
| Open AccessPrevalence of persistent SARS-CoV-2 in a large community surveillance study
Using viral sequence data, individuals with persistent SARS-CoV-2 infections were identified, and had higher odds of self-reporting long COVID, in a large community surveillance study.
- Mahan Ghafari
- , Matthew Hall
- & Katrina Lythgoe
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Correspondence |
Stockholm declaration on AI ethics: why others should sign
- Ross D. King
- , Teresa Scassa
- & Hiroaki Kitano
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World View |
Generative AI’s environmental costs are soaring — and mostly secret
First-of-its-kind US bill would address the environmental costs of the technology, but there’s a long way to go.
- Kate Crawford
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Article
| Open AccessGenetic drivers of heterogeneity in type 2 diabetes pathophysiology
A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.
- Ken Suzuki
- , Konstantinos Hatzikotoulas
- & Eleftheria Zeggini
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Article
| Open AccessGenomic data in the All of Us Research Program
A study describes the release of clinical-grade whole-genome sequence data for 245,388 diverse participants by the All of Us Research Program and characterizes the properties of the dataset.
- Alexander G. Bick
- , Ginger A. Metcalf
- & Joshua C. Denny
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News Explainer |
What the EU’s tough AI law means for research and ChatGPT
The EU AI Act is the world’s first major legislation on artificial intelligence and strictly regulates general-purpose models.
- Elizabeth Gibney
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News Explainer |
How journals are fighting back against a wave of questionable images
Publishers are deploying AI-based tools to detect suspicious images, but generative AI threatens their efforts.
- Nicola Jones
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News |
Apple Vision Pro: what does it mean for scientists?
The headset opens up possibilities in accessibility and medical research — and raises concerns about human behaviour.
- Jonathan O'Callaghan
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News |
AI chatbot shows surprising talent for predicting chemical properties and reactions
Researchers lightly tweak ChatGPT-like system to offer chemistry insight.
- Davide Castelvecchi
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Career Column |
‘Obviously ChatGPT’ — how reviewers accused me of scientific fraud
A journal reviewer accused Lizzie Wolkovich of using ChatGPT to write a manuscript. She hadn’t — but her paper was rejected anyway.
- E. M. Wolkovich
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News |
First passages of rolled-up Herculaneum scroll revealed
Researchers used artificial intelligence to decipher the text of 2,000-year-old charred papyrus scripts, unveiling musings on music and capers.
- Jo Marchant
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Career Column |
In the AI science boom, beware: your results are only as good as your data
Machine-learning systems are voracious data consumers — but trustworthy results require more vetting both before and after publication.
- Hunter Moseley
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News |
This AI learnt language by seeing the world through a baby’s eyes
A neural network that taught itself to recognize objects using the filmed experiences of a single infant could offer new insights into how humans learn.
- Elizabeth Gibney
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Editorial |
How can scientists make the most of the public’s trust in them?
Researchers have a part to play in addressing concerns about government interference in science.
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Article |
Conformational ensembles of the human intrinsically disordered proteome
A computational model generates conformational ensembles of 28,058 intrinsically disordered proteins and regions (IDRs) in the human proteome and sheds light on the relationship between sequence, conformational properties and functions of IDRs.
- Giulio Tesei
- , Anna Ida Trolle
- & Kresten Lindorff-Larsen
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Article
| Open AccessSHR and SCR coordinate root patterning and growth early in the cell cycle
Quantitative time-resolved microscopy analysis of SHR and SCR dynamics in single cells of living Arabidopsis roots shows that these transcription factors coordinate formative and proliferative cell divisions early in the cell cycle.
- Cara M. Winter
- , Pablo Szekely
- & Philip N. Benfey
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Outlook |
Tracking down tuberculosis
Improvements in screening and diagnosis could help to eradicate this curable disease.
- Neil Savage
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Correspondence |
Tech developers must respect equitable AI access
- Michał Choraś
- , Marek Pawlicki
- & Aleksandra Pawlicka
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