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| Open AccessIntegrated intracellular organization and its variations in human iPS cells
A dataset of 3D images from more than 200,000 human induced pluripotent stem cells is used to develop a framework to analyse cell shape and the location and organization of major intracellular structures.
- Matheus P. Viana
- , Jianxu Chen
- & Susanne M. Rafelski
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Article |
Whole-cell organelle segmentation in volume electron microscopy
Focused ion beam scanning electron microscopy (FIB-SEM) combined with deep-learning-based segmentation is used to produce three-dimensional reconstructions of complete cells and tissues, in which up to 35 different organelle classes are annotated.
- Larissa Heinrich
- , Davis Bennett
- & Destiny Nguyen
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Article |
AI-based pathology predicts origins for cancers of unknown primary
A deep-learning-based algorithm uses routinely acquired histology slides to provide a differential diagnosis for the origin of the primary tumour for complicated cases of metastatic tumours and cancers of unknown primary origin.
- Ming Y. Lu
- , Tiffany Y. Chen
- & Faisal Mahmood
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Article |
A multi-modal parcellation of human cerebral cortex
A detailed parcellation (map) of the human cerebral cortex has been obtained by integrating multi-modal imaging data, including functional magnetic resonance imaging (fMRI), and the resulting freely available resources will enable detailed comparative studies of the human brain in health, ageing and disease.
- Matthew F. Glasser
- , Timothy S. Coalson
- & David C. Van Essen
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Letter |
Polarized endosome dynamics by spindle asymmetry during asymmetric cell division
Central spindle asymmetry, generated by the kinesin Klp10A and its antagonist Patronin, polarizes endosome motility and provides a mechanism for the asymmetric segregation of signalling endosomes observed in a variety of asymmetrically dividing cell types.
- Emmanuel Derivery
- , Carole Seum
- & Marcos Gonzalez-Gaitan