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Mathematical modelling of 15 years of data from South Africa reveals the spread and vaccine-driven changes in fitness and antimicrobial resistance of Streptococcus pneumoniae.
The magnetic fields of an individual lattice plane inside materials with a non-uniform structure were observed under magnetic-field-free conditions by electron holography.
Myddosomes, in which MyD88 forms barrel-like scaffold structures for effector protein recruitment and activation, contain proteins that act at all stages and regulate all effector responses of the TLR signalling pathways.
A study describes a new giant stem tetrapod, Gaiasia jennyae, from high-palaeolatitude early Permian-aged deposits in Namibia that challenges current hypotheses of early tetrapod evolution.
A global survey on the magnitude and persistence of moist forest cover change and canopy height following degradation using satellite remote sensing data finds that the effects are substantial and persist for decades.
Zinc-finger proteins ZNF512 and ZNF512B are shown to target pericentric DNA through a conserved mechanism that depends on their atypical long linkers, providing insight into how constitutive heterochromatin formation is initiated across various species.
A cave art scene at Leang Karampuang, Indonesia, dated to at least 51,200 years ago using laser-ablation uranium-series imaging, depicts human-like figures interacting with a pig.
Pseudovirus-based SARS-CoV-2 spike deep mutational scanning is used to measure how mutations across the spikes affect ACE2 binding, cell entry or escape from human sera, producing data that could enable better prediction of viral evolution.
By using a photonic synthetic lattice, it can be experimentally demonstrated that Dirac masses can be induced by means of non-Hermitian perturbations based on optical gain and loss.
Cryogenic electron microscopy structures of Mycobacterium tuberculosis ATP synthase and human ATP synthase bound to the anti-tuberculosis drug bedaquiline or its analogue TBAJ-587 shed light on drug binding and could lead to new treatments for tuberculosis.
Evidence of modulated metallic and superconducting states stemming from an incommensurate structural stripe motif is reported in the bulk van der Waals superlattice SrTa2S5.
By tracking the activity of individual neurons using microarrays and Neuropixels probes, a study examines the representation of linguistic meaning, at the single-cell level, during natural speech processing in humans.
Zooarchaeological and proteomic analyses of bones from Baishiya Karst Cave on the Tibetan Plateau identify a hominin rib specimen, and provide insight into the ways Denisovans interacted with their surrounding environment and made use of animal resources.
Layer-stacking domain walls in van der Waals heterostructures form a broadly tunable Luttinger liquid system, including both isolated and coupled arrays.
A newly discovered negative allosteric modulator of the µ-opioid receptor works together with naloxone to potently block opioid agonist signalling with reduced adverse effects.
Experiments in mice show that brain circuitry centred on the posteromedial nucleus of the cortical amygdala has a key role in consolidating socially transmitted long-term memories.
Lactylation of NBS1 by TIP60 promotes homologous recombination-driven DNA repair and resistance to chemotherapy in cancer cells and links altered cancer cell metabolism to increase genome stability.
This study explores how adenosine A2B receptors can act as astrocytic sensors of brain metabolic activity and how cAMP signalling in astrocytes may support core brain functions such as sleep and memory.
Three-dimensional photo-printable resin chemistry yields an elastomer with tensile strength of 94.6 MPa and toughness of 310.4 MJ m−3, both of which far exceed that of any three-dimensional printed elastomer.