Technology Feature |
Featured
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Nature Podcast |
Why ‘open source’ AIs could be anything but, the derailment risks of long freight trains, and breeding better wheat
We round up some recent stories from the Nature Briefing.
- Nick Petrić Howe
- , Benjamin Thompson
- & Dan Fox
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Correspondence |
AI machine translation tools must be taught cultural differences too
- Helene Tenzer
- , Stefan Feuerriegel
- & Rebecca Piekkari
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News & Views |
‘Fighting fire with fire’ — using LLMs to combat LLM hallucinations
The number of errors produced by an LLM can be reduced by grouping its outputs into semantically similar clusters. Remarkably, this task can be performed by a second LLM, and the method’s efficacy can be evaluated by a third.
- Karin Verspoor
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News |
Not all ‘open source’ AI models are actually open: here’s a ranking
Many of the large language models that power chatbots claim to be open, but restrict access to code and training data.
- Elizabeth Gibney
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Article
| Open AccessComputational design of soluble and functional membrane protein analogues
A deep learning approach enables accurate computational design of soluble and functional analogues of membrane proteins, expanding the soluble protein fold space and facilitating new approaches to drug screening and design.
- Casper A. Goverde
- , Martin Pacesa
- & Bruno E. Correia
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Article
| Open AccessMultiscale topology classifies cells in subcellular spatial transcriptomics
A method for topological automatic cell type classification across subcellular resolution spatial transcriptomic platforms is proposed, resolving cell type information and locating sparsely dispersed cells in human kidney and mouse kidney and brain.
- Katherine Benjamin
- , Aneesha Bhandari
- & Katherine R. Bull
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Article
| Open AccessHuman SARS-CoV-2 challenge uncovers local and systemic response dynamics
A human SARS-CoV-2 challenge study in individuals without previous exposure to the virus or vaccines provides detailed profiles of local and systemic epithelial and immune cell response dynamics over time and infection status.
- Rik G. H. Lindeboom
- , Kaylee B. Worlock
- & Sarah A. Teichmann
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News Q&A |
AI and Euro 2024: VAR is shaking up football — and it’s not going away
Sports physicist Eric Goff explains how updates to the technology can help referees to make the toughest calls.
- Sumeet Kulkarni
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Article |
A Multimodal Generative AI Copilot for Human Pathology
- Ming Y. Lu
- , Bowen Chen
- & Faisal Mahmood
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Article
| Open AccessStrand-resolved mutagenicity of DNA damage and repair
How strand-asymmetric processes such as replication and transcription interact with DNA damage to drive mechanisms of repair and mutagenesis is explored.
- Craig J. Anderson
- , Lana Talmane
- & Martin S. Taylor
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Editorial |
Meta’s AI system is a boost to endangered languages — as long as humans aren’t forgotten
Automated approaches to translation could provide a lifeline to under-resourced languages, but only if companies engage with the people who speak them.
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Career Column |
Need a policy for using ChatGPT in the classroom? Try asking students
Students are the key users of AI chatbots in university settings, but their opinions are rarely solicited when crafting policies. That needs to change, says Maja Zonjić.
- Maja Zonjić
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News & Views |
Meta’s AI translation model embraces overlooked languages
More than 7,000 languages are in use throughout the world, but popular translation tools cannot deal with most of them. A translation model that was tested on under-represented languages takes a key step towards a solution.
- David I. Adelani
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Article
| Open AccessSingle-cell nascent RNA sequencing unveils coordinated global transcription
Nascent transcription in genes and enhancers genome-wide at the single-cell level is quantified using global run-on and sequencing (GRO–seq) with click chemistry.
- Dig B. Mahat
- , Nathaniel D. Tippens
- & Phillip A. Sharp
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News |
Superfast Microsoft AI is first to predict air pollution for the whole world
The model, called Aurora, also forecasts global weather for ten days — all in less than a minute.
- Carissa Wong
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News Feature |
How cutting-edge computer chips are speeding up the AI revolution
Engineers are harnessing the powers of graphics processing units (GPUs) and more, with a bevy of tricks to meet the computational demands of artificial intelligence.
- Dan Garisto
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Outlook |
AI assistance for planning cancer treatment
Armed with the right data, advances in machine learning could help oncologists to home in quickly on the best treatment strategies for their patients.
- Michael Eisenstein
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Nature Podcast |
How AI could improve robotics, the cockroach’s origins, and promethium spills its secrets
We round up some recent stories from the Nature Briefing.
- Benjamin Thompson
- , Elizabeth Gibney
- & Flora Graham
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News Explainer |
Who owns your voice? Scarlett Johansson OpenAI complaint raises questions
In the age of artificial intelligence, situations are emerging that challenge the laws over rights to a persona.
- Nicola Jones
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Article
| Open AccessThe complete sequence and comparative analysis of ape sex chromosomes
Reference assemblies of great ape sex chromosomes show that Y chromosomes are more variable in size and sequence than X chromosomes and provide a resource for studies on human evolution and conservation genetics of non-human apes.
- Kateryna D. Makova
- , Brandon D. Pickett
- & Adam M. Phillippy
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Correspondence |
Anglo-American bias could make generative AI an invisible intellectual cage
- Queenie Luo
- & Michael Puett
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News Feature |
The AI revolution is coming to robots: how will it change them?
The melding of artificial intelligence and robotics could catapult both fields to new heights.
- Elizabeth Gibney
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Nature Podcast |
Audio long read: How does ChatGPT ‘think’? Psychology and neuroscience crack open AI large language models
To understand the 'brains' of LLMs, researchers are attempting to reverse-engineering artificial intelligence systems.
- Matthew Hutson
- & Benjamin Thompson
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News |
Superstar porous materials get salty thanks to computer simulations
Model predicts the structure of previously elusive compounds with practical applications.
- Ariana Remmel
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Editorial |
AlphaFold3 — why did Nature publish it without its code?
Criticism of our decision to publish AlphaFold3 raises important questions. We welcome readers’ views.
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News & Views |
AI networks reveal how flies find a mate
Artificial neural networks that model the visual system of a male fruit fly can accurately predict the insect’s behaviour in response to seeing a potential mate — paving the way for the building of more complex models of brain circuits.
- Pavan Ramdya
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News |
China’s ChatGPT: why China is building its own AI chatbots
ChatGLM is one of hundreds of AI language models being developed for the Chinese language. It comes close to ChatGPT on many measures, say its creators.
- Celeste Biever
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Article
| Open AccessMolecular mechanism of choline and ethanolamine transport in humans
Structural analysis of the human choline and ethanolamine transporters FLVCR1 and FLVCR2 clarifies the mechanisms of transport, the conformational dynamics of these proteins and the disease-associated mutations that interfere with these processes.
- Keiken Ri
- , Tsai-Hsuan Weng
- & Schara Safarian
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News |
First ‘bilingual’ brain-reading device decodes Spanish and English words
Artificial-intelligence system allows a man who cannot speak coherently to have a conversation in the language of his choice.
- Amanda Heidt
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Technology Feature |
DeepLabCut: the motion-tracking tool that went viral
Mackenzie and Alexander Mathis were still early in their careers when their software created a sensation. Now they’re using it to support other young scientists.
- Jyoti Madhusoodanan
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World View |
Why mathematics is set to be revolutionized by AI
Cheap data and the absence of coincidences make maths an ideal testing ground for AI-assisted discovery — but only humans will be able to tell good conjectures from bad ones.
- Thomas Fink
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News Feature |
How does ChatGPT ‘think’? Psychology and neuroscience crack open AI large language models
Researchers are striving to reverse-engineer artificial intelligence and scan the ‘brains’ of LLMs to see what they are doing, how and why.
- Matthew Hutson
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News Q&A |
The US Congress is taking on AI — this computer scientist is helping
Kiri Wagstaff, who temporarily shelved her academic career to provide advice on federal AI legislation, talks about life inside the halls of power.
- Nicola Jones
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Research Briefing |
‘Ghost roads’ could be the biggest direct threat to tropical forests
By using volunteers to map roads in forests across Borneo, Sumatra and New Guinea, an innovative study shows that existing maps of the Asia-Pacific region are rife with errors. It also reveals that unmapped roads are extremely common — up to seven times more abundant than mapped ones. Such ‘ghost roads’ are promoting illegal logging, mining, wildlife poaching and deforestation in some of the world’s biologically richest ecosystems.
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News |
Major AlphaFold upgrade offers boost for drug discovery
Latest version of the AI models how proteins interact with other molecules — but DeepMind restricts access to the tool.
- Ewen Callaway
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Article
| Open AccessAccurate structure prediction of biomolecular interactions with AlphaFold 3
AlphaFold 3 has a substantially updated architecture that is capable of predicting the joint structure of complexes including proteins, nucleic acids, small molecules, ions and modified residues with greatly improved accuracy over many previous specialized tools.
- Josh Abramson
- , Jonas Adler
- & John M. Jumper
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Article
| Open AccessThe intrinsic substrate specificity of the human tyrosine kinome
An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase regulation in phosphoproteomics experiments.
- Tomer M. Yaron-Barir
- , Brian A. Joughin
- & Jared L. Johnson
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Article
| Open AccessComputationally restoring the potency of a clinical antibody against Omicron
By demonstrating a computational approach to restore the clinical efficacy of a COVID-19 antibody, the potential to rapidly update clinical antibodies is explored.
- Thomas A. Desautels
- , Kathryn T. Arrildt
- & Daniel M. Faissol
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News |
Who’s making chips for AI? Chinese manufacturers lag behind US tech giants
Researchers in China say they are finding themselves five to ten years behind their US counterparts as export restrictions bite.
- Jonathan O'Callaghan
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News |
‘ChatGPT for CRISPR’ creates new gene-editing tools
Some of the AI-designed gene editors could be more versatile than those found in nature.
- Ewen Callaway
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Technology Feature |
85 million cells — and counting — at your fingertips
Chan Zuckerberg CELL by GENE Discover aims to be a one-stop shop for single-cell RNA sequencing data storage, access and analysis.
- Jeffrey M. Perkel
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News Feature |
Lethal AI weapons are here: how can we control them?
Autonomous weapons guided by artificial intelligence are already in use. Researchers, legal experts and ethicists are struggling with what should be allowed on the battlefield.
- David Adam
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Comment |
Will AI accelerate or delay the race to net-zero emissions?
As artificial intelligence transforms the global economy, researchers need to explore scenarios to assess how it can help, rather than harm, the climate.
- Amy Luers
- , Jonathan Koomey
- & Eric Horvitz
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Outlook |
AI’s keen diagnostic eye
Powered by deep-learning algorithms, artificial intelligence systems could replace agents such as chemicals currently used to augment medical scans.
- Neil Savage
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Nature Video |
AI and robotics demystify the workings of a fly's wing
New research unveils the workings of one of the most complex bio-mechanical structures in the natural world
- Dan Fox
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News |
AI traces mysterious metastatic cancers to their source
Algorithm examines images of metastatic cells to identify the location of the primary tumour.
- Smriti Mallapaty
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News |
AI now beats humans at basic tasks — new benchmarks are needed, says major report
Stanford University’s 2024 AI Index charts the meteoric rise of artificial-intelligence tools.
- Nicola Jones
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News |
Is ChatGPT corrupting peer review? Telltale words hint at AI use
A study of review reports identifies dozens of adjectives that could indicate text written with the help of chatbots.
- Dalmeet Singh Chawla
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Article
| Open AccessEmergence of fractal geometries in the evolution of a metabolic enzyme
Citrate synthase from the cyanobacterium Synechococcus elongatus is shown to self-assemble into Sierpiński triangles, a finding that opens up the possibility that other naturally occurring molecular-scale fractals exist.
- Franziska L. Sendker
- , Yat Kei Lo
- & Georg K. A. Hochberg
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