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Lou may refer to:
- Characters:
- Lieutenant, also known as Lou, a cyborg super mutant and right-hand-man of the Master in Fallout.
- Lou (Nightkin), a Nightkin invader, cut from Fallout.
- Louise, also known as Lou, the bartender of the Malamute Saloon in Redding in Fallout 2.
- Cindy-Lou Kreb, a human resources employee at the H&H Tools Company, mentioned in Fallout: New Vegas.
- Lou Martin, an employee of M&M Construction, mentioned in the Fallout: New Vegas add-on Dead Money.
- Maria Lou, a character in the Wastelad holotape game in Fallout 76.
- Lucky Lou, an elderly ghoul member of the Crater Raiders in the Fallout 76 update Wastelanders.
- Lou (Nuka-World on Tour), a patient of Del Walsh, mentioned in the Fallout 76 update Nuka-World on Tour.
- Items:
- Apologies to Lou, a holotape by Caleb Fisher in the Fallout 76 update Wastelanders.
- Lou's goodbye note, a paper note written by Lucky Lou in the Fallout 76 update Wastelanders.
- Lou's log: Cave-in, a paper note written by Lucky Lou in the Fallout 76 update Wastelanders.
- Lou's log: Chamber, a paper note written by Lucky Lou in the Fallout 76 update Wastelanders.
- Lou's log: Engine room, a paper note written by Lucky Lou in the Fallout 76 update Wastelanders.
- Lou's log: New plan, a paper note written by Lucky Lou in the Fallout 76 update Wastelanders.
- Lou's log: Turret repair, a paper note written by Lucky Lou in the Fallout 76 update Wastelanders.
- Lou's remote detonator, a miscellaneous quest item in the Fallout 76 update Wastelanders.