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Open Access
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Article
| Open AccessEarly-childhood linear growth faltering in low- and middle-income countries
A pooled analysis of longitudinal studies in low- and middle-income countries identifies the typical age of onset of linear growth faltering and investigates recurrent faltering in early life.
- Jade Benjamin-Chung
- , Andrew Mertens
- & Pablo Penataro Yori
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World View |
A new model for public health in Africa can become a reality
As Africa emerges from the COVID pandemic, combating infectious diseases must be a priority — along with treating non-communicable and mental health conditions.
- Jean Kaseya
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News |
Strike at outbreak-alert service ProMED to end — but tensions remain
Most of the striking ProMED staff members are prepared to return to work, although many still have concerns.
- Max Kozlov
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News Feature |
A DIY ‘bionic pancreas’ is changing diabetes care — what's next?
A community of people with type 1 diabetes got a self-built device approved. What can they offer that big companies can’t?
- Liam Drew
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Article
| Open AccessAn orexigenic subnetwork within the human hippocampus
An appetite-regulating subnetwork in humans involving the lateral hypothalamus and the dorsolateral hippocampus is implicated in obesity and related eating disorders.
- Daniel A. N. Barbosa
- , Sandra Gattas
- & Casey H. Halpern
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Article
| Open AccessGut microbial carbohydrate metabolism contributes to insulin resistance
Faecal carbohydrates, particularly host-accessible monosaccharides, are increased in individuals with insulin resistance and are associated with microbial carbohydrate metabolisms and host inflammatory cytokines.
- Tadashi Takeuchi
- , Tetsuya Kubota
- & Hiroshi Ohno
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Article |
Endothelial AHR activity prevents lung barrier disruption in viral infection
The environmental sensor aryl hydrocarbon receptor (AHR) and diet-derived AHR ligands play an important part in protecting against tissue damage following viral pathogen infection in the lung.
- Jack Major
- , Stefania Crotta
- & Andreas Wack
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News Explainer |
Anti-obesity drug also protects against heart disease — what happens next?
Clinical-trial data suggest that semaglutide, sold under the name Wegovy, slashes risk of heart attacks and other cardiovascular incidents.
- Mariana Lenharo
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News |
Key alert system for disease outbreaks is in crisis — can it be saved?
ProMED staff members look for rescue options, after going on strike and calling for new leadership and financing.
- Max Kozlov
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Article
| Open AccessDissecting human population variation in single-cell responses to SARS-CoV-2
Population differences in immune responses to SARS-CoV-2 can be explained by environmental exposures, but also by local adaptation acting through genetic variants acquired after admixture with archaic hominin forms.
- Yann Aquino
- , Aurélie Bisiaux
- & Lluis Quintana-Murci
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Matters Arising |
Reply to: Revisiting the intrinsic mycobiome in pancreatic cancer
- Fangxi Xu
- , Deepak Saxena
- & George Miller
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News & Views |
How the cGAS–STING system links inflammation and cognitive decline
When DNA is misplaced inside cells, the cGAS–STING molecular system triggers inflammation. It emerges that stimulation of this mechanism in microglial cells of the brain during ageing contributes to cognitive decline.
- Bart J. L. Eggen
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News Feature |
Four key questions on the new wave of anti-obesity drugs
Scientists want to know who will benefit most, what the long-term effects might be and whether the treatments will change views on obesity.
- McKenzie Prillaman
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Article |
Africa-specific human genetic variation near CHD1L associates with HIV-1 load
Africa-specific genetic variation on chromosome 1 near CHD1L is associated with HIV replication in vivo.
- Paul J. McLaren
- , Immacolata Porreca
- & Jacques Fellay
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News |
NIH launches trials for long COVID treatments: what scientists think
World’s largest study of long COVID will evaluate potential therapies for brain fog, sleep disruption and more.
- Max Kozlov
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News |
Experimental insulin implant uses electricity to control genes
Human cells that have been engineered to respond to an electrical current could be incorporated into future medical devices.
- Lilly Tozer
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News |
Dengue is breaking records in the Americas — what’s behind the surge?
Increasing temperatures contribute to longer dengue seasons, and could drive the geographical expansion of the disease.
- Mariana Lenharo
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News |
As COVID-19 cases rose, so did diabetes — no one knows why
The spike in childhood type 1 diabetes opened new avenues for researchers to explore the cause of the disease.
- Clare Watson
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Perspective |
The complementarity of DDR, nucleic acids and anti-tumour immunity
This Perspective reviews advances in the understanding of the intersection between the DNA damage response and the response to immune checkpoint blockade therapy, and discusses how developments in the field could lead to improved anti-cancer therapies.
- Anand V. R. Kornepati
- , Cody M. Rogers
- & Tyler J. Curiel
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Article
| Open AccessA common allele of HLA is associated with asymptomatic SARS-CoV-2 infection
The human leukocyte antigen allele HLA-B*15:01 is associated with asymptomatic SARS-CoV-2 infection due to pre-existing T cell immunity.
- Danillo G. Augusto
- , Lawton D. Murdolo
- & Jill A. Hollenbach
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News |
Alzheimer’s drug donanemab helps most when taken at earliest disease stage, study finds
But the drug, an antibody that attacks the protein amyloid, does not work as well in people with more advanced disease.
- Sara Reardon
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Technology Feature |
Germs, genes and soil: tales of pathogens past
Armed with DNA sequencers and powerful computational tools, archaeogeneticists are turning their attention towards ancient microbes to give bacteria their due in human history.
- Amber Dance
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Clinical Briefing |
A framework for identifying targets for individualized therapy in genetic disease
Researchers have developed a system to classify genetic mutations that could be addressed by therapeutic interventions that use ‘splice-switching antisense oligonucleotides’. This framework identified multiple eligible mutations among 235 people with the genetic disorder ataxia–telangiectasia. An oligonucleotide that was specific to one of these mutations was advanced to a proof-of-concept individualized trial.
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Article
| Open AccessPLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection
Phospholipid scramblase 1 (PLSCR1), a protein induced by IFNγ, acts as a defence factor against SARS-CoV-2 and other coronaviruses by inhibiting the fusion of the virus with host-cell membranes.
- Dijin Xu
- , Weiqian Jiang
- & John D. MacMicking
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Article |
A planetary health innovation for disease, food and water challenges in Africa
By harvesting aquatic vegetation that provides habitat for snails that harbour Schistosoma parasites and converting it to compost and animal feed, a trial reduced schistosomiasis prevalence in children while providing wider economic benefits.
- Jason R. Rohr
- , Alexandra Sack
- & Caitlin Wolfe
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Article
| Open AccessA framework for individualized splice-switching oligonucleotide therapy
Whole-genome sequencing analyses in a cohort of individuals with ataxia-telangiectasia are used to identify genetic variants that might be amenable to treatment with splice-switching antisense oligonucleotides (ASOs), and develop ASOs with therapeutic potential.
- Jinkuk Kim
- , Sijae Woo
- & Timothy W. Yu
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Correspondence |
Women’s health: tackle the research funding deficit
- Krina T. Zondervan
- , Linda G. Griffith
- & Stacey A. Missmer
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News |
Anti-ageing protein injection boosts monkeys’ memories
First primate studies to show cognitive benefits of the protein klotho could be a step towards clinical applications.
- Lilly Tozer
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News |
Australia to prescribe MDMA and psilocybin for PTSD and depression in world first
Decision to make the previously illicit drugs available is dogged by suggestions that it was rushed.
- Rich Haridy
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Outlook |
Battling a health crisis in the Amazon
Scientists are racing to control malaria in northern Brazil where the disease is playing a major part in the current health emergency threatening the region’s Indigenous people.
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Outlook |
The challenges facing scientists in the elimination of malaria
The world now has a malaria vaccine, but it won’t be enough to wipe out the parasitic disease
- Richard Hodson
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News |
Promising tuberculosis vaccine gets US$550-million shot in the arm
The candidate is moving to long-awaited phase III trials — if successful, it would be the first new jab against the disease in more than 100 years.
- Lilly Tozer
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Outlook |
Malaria’s modelling problem
Southern Africa wants to eliminate the disease by 2030, but predicting where and when the disease will strike remains a challenge.
- Linda Nordling
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Outlook |
Can malaria researchers slow the spread of drug resistance?
Concerns that artemisinin combination treatments are losing their effectiveness against Plasmodium parasites have set scientists looking for alternatives.
- T. V. Padma
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Outlook |
The next frontier for malaria vaccination
Hot on the heels of the first approved vaccine for malaria, researchers are racing to develop even better shots that tackle the parasite at every stage of its life cycle.
- Cassandra Willyard
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Outlook |
Malaria: highlights from research
A mosquito hibernation mystery solved, parasites grown in dishes for the first time, and other studies and trials.
- Laura Vargas-Parada
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Outlook |
In search of a vaccine for Plasmodium vivax malaria
Vaccinologist Arturo Reyes-Sandoval explains how researchers are edging closer to a much-needed vaccine.
- Laura Vargas-Parada
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Outlook |
Monoclonal antibodies show promise for malaria prevention
Immunologist Robert Seder and malaria epidemiologist Kassoum Kayentao talk to Nature about their work and how they think the parasitic disease could be controlled in the future.
- Cassandra Willyard
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Outlook |
How genetically modified mosquitoes could eradicate malaria
Gene-drive technology that can spread antimalarial modifications throughout mosquito populations is maturing, but there are questions to answer before it can be used in the wild.
- Sam Jones
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Research Briefing |
Energy burn in muscle boosted by a hormonal signalling axis
Restricting dietary calories leads to weight loss, but with time these effects diminish because the body’s metabolism slows down. A hormone called GDF15 is now shown to maintain weight loss during dieting by promoting energy expenditure through the activation of pathways that affect calcium levels in skeletal muscle.
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Article
| Open AccessGDF15 promotes weight loss by enhancing energy expenditure in muscle
GDF15 treatment in mice counteracts compensatory reductions in energy expenditure, resulting in greater weight loss and reductions in non-alcoholic fatty liver disease compared to caloric restriction alone.
- Dongdong Wang
- , Logan K. Townsend
- & Gregory R. Steinberg
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Article |
Locus for severity implicates CNS resilience in progression of multiple sclerosis
A genome-wide association study including 22,389 cases of multiple sclerosis finds an association with disease progression at the DYSF–ZNF638 and DNM3–PIGC loci and identifies a potential of higher educational attainment in slowing disease progression.
- Adil Harroud
- , Pernilla Stridh
- & Kári Stefánsson
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Correspondence |
Autism: don’t negate the value of applied behaviour analysis
- Gina Green
- , Russell Lang
- & Jason Travers
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News |
Beyond Ozempic: brand-new obesity drugs will be cheaper and more effective
Hormone mimics offer advantages even beyond those of the potent weight-loss jabs on the market now.
- Saima Sidik
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Spotlight |
By the numbers: China’s changing diet
Data show that the Chinese middle class is eating a higher-fat, less-healthy diet — a trend reflected in the increases in heart disease and childhood obesity.
- Yvaine Ye
- & Jack Leeming
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Article |
Y chromosome loss in cancer drives growth by evasion of adaptive immunity
Loss of the Y chromosome in tumour cells is associated with a poor prognosis for patients with bladder cancer by causing local T cell exhaustion, which also increases the response to immune checkpoint blockade therapy.
- Hany A. Abdel-Hafiz
- , Johanna M. Schafer
- & Dan Theodorescu
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News |
Mum’s microbes might boost brain development of c-section babies
Vaginal seeding is safe and seems to benefit infants delivered by the surgery — but larger trials are needed.
- Ewen Callaway
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