Featured
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News |
‘Epigenome editor’ silences gene that causes deadly brain disorders
Prion diseases are caused by misfolded proteins, but a new tool can stop them forming in mice.
- Gemma Conroy
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News |
How blockbuster obesity drugs create a full feeling — even before one bite of food
Scientists identify brain area harbouring two groups of neurons: one for pre-meal sensations of fullness, and one for post-meal satiety.
- Mariana Lenharo
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News |
Ketamine for depression: slow-release pills could make treatment more accessible
A ketamine-containing tablet could be a convenient alternative to intravenous treatments, with fewer unpleasant side effects.
- Helena Kudiabor
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News |
Does Ozempic boost fertility? What the science says
Blockbuster weight-loss drugs have been linked to unexplained pregnancies. Research shows it is plausible, but more data are needed.
- Gillian Dohrn
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News |
Estonians gave their DNA to science — now they’re learning their genetic secrets
Project covering one-fifth of the country’s population is one of the largest-ever efforts to share results on genetic health risks with research participants.
- Ewen Callaway
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World View |
Put people at the heart of schizophrenia research
Scientists, health-care professionals, carers and individuals affected by the condition must work more closely with one another to improve people’s lives.
- Constanza Morén
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Outlook |
Could rats and dogs detect disease better than the finest lab equipment?
The animals’ keen sense of smell could improve the detection of illnesses such as cancer and tuberculosis.
- Sarah DeWeerdt
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News |
Cheaper versions of blockbuster obesity drugs are being created in India and China
As the patents on various weight-loss drugs near expiry, companies in India and China are vying to make lower-cost versions that will widen access to such treatments.
- Smriti Mallapaty
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Research Briefing |
Brain senses immune reactions in the body through the vagus nerve
A newly characterized neural circuit enables the brain to sense and monitor inflammatory responses in the body, and in turn shape the course of the immune reaction. Artificial activation of components of this body–brain circuit in mouse models of inflammation and immune disorders prevented uncontrolled and dysregulated inflammatory reactions.
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Article
| Open AccessStrand-resolved mutagenicity of DNA damage and repair
How strand-asymmetric processes such as replication and transcription interact with DNA damage to drive mechanisms of repair and mutagenesis is explored.
- Craig J. Anderson
- , Lana Talmane
- & Martin S. Taylor
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News |
Alzheimer’s drug with modest benefits wins backing of FDA advisers
Donanemab slows progression of symptoms, but questions linger about the durability of its effect.
- Sara Reardon
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News |
MDMA therapy for PTSD rejected by FDA panel
Scientific advisers to the US Food and Drug Administration vote overwhelmingly that the risks of MDMA treatment for post-traumatic stress disorder outweigh the benefits.
- Sara Reardon
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News & Views |
Brain fluid probed by ultrasound using squishy cubes
Soft solids that swell with shifts in pressure, temperature and pH provide a way of detecting such changes in the fluid around the brain. The method could be used to determine other properties of fluids elsewhere in the body.
- Jules J. Magda
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News & Views |
Father’s diet influences son’s metabolic health through sperm RNA
DNA from organelles called mitochondria is not inherited from the father. But mitochondrial RNAs that sense paternal diet and mitochondrial quality are delivered from sperm to egg, affecting offspring metabolism.
- Chen Cai
- & Qi Chen
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News |
A dad’s diet affects his sperm — and his sons’ health
Mouse fathers who ate high-fat foods and human fathers with high body-mass index have male offspring with metabolic disorders.
- Julian Nowogrodzki
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News |
Huge amounts of bird-flu virus found in raw milk of infected cows
New findings point to the milking process as a possible route of avian-influenza spread between cows — and from cow to human.
- Max Kozlov
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Outlook |
Innovative cancer therapies offer new hope
The arsenal of weapons used to treat these insidious diseases is rapidly expanding.
- Herb Brody
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Outlook |
Advances in highly targeted radiation treatment for cancer have ignited interest in a once obscure field
Therapies that treat while diagnosing — theranostics — can extend length of survival and improve the quality of life for some people with advance-stage cancer.
- Rachel Nuwer
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News & Views |
Pollen problems: May brings dismay to a hay-fever sufferer in 1874
A book on everyday biology that appeals to non-specialists and specialists alike, and a trek through hay fields causes one Nature reader to experience relentless ‘sneezings’, in the weekly dip into Nature’s archive.
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News |
Autistic people three times more likely to develop Parkinson’s-like symptoms
Largest study of its kind also finds increased risk in older adults with a range of intellectual disabilities.
- Miryam Naddaf
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News |
Ozempic keeps wowing: trial data show benefits for kidney disease
Semaglutide, the same compound in obesity drug Wegovy, slashes risk of kidney failure and death for people with diabetes.
- Rachel Fairbank
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News & Views |
Neural pathways for reward and relief promote fentanyl addiction
Neuroscientists find that two distinct neural pathways are responsible for the addictive properties of the opioid fentanyl: one mediates reward, the other promotes the seeking of relief from symptoms of withdrawal.
- Markus Heilig
- & Michele Petrella
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Article |
Covalent targeted radioligands potentiate radionuclide therapy
Radiopharmaceuticals engineered with click chemistry to selectively bind to tumour-specific proteins can be used to successfully target tumour cells, boosting the pharmacokinetics of radionuclide therapy and improving tumour regression.
- Xi-Yang Cui
- , Zhu Li
- & Zhibo Liu
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Article
| Open AccessA whole-slide foundation model for digital pathology from real-world data
Prov-GigaPath, a whole-slide pathology foundation model pretrained on a large dataset containing around 1.3 billion pathology images, attains state-of-the-art performance in cancer classification and pathomics tasks.
- Hanwen Xu
- , Naoto Usuyama
- & Hoifung Poon
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Correspondence |
Internet use and teen mental health: it’s about more than just screen time
- Linxiao Zhang
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Correspondence |
Social-media influence on teen mental health goes beyond just cause and effect
- Michael A. Spikes
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Clinical Briefing |
mRNA therapy is safe for treating the inherited metabolic condition propionic acidaemia
Propionic acidaemia is an inheirited metabolic condition caused by a lack of a liver enzyme, which leads to accumulation of toxic compounds. In a first-in-human trial, a therapeutic messenger RNA drug (mRNA-3927) led to restored enzyme activity, was well tolerated and showed a promising dose-dependent reduction of potentially life-threatening clinical events.
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News |
Gut microbes linked to fatty diet drive tumour growth
Scientists know there is a link between obesity and some cancers. A study in mice and people suggests why that might be.
- Gillian Dohrn
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News & Views |
Dual-action obesity drug rewires brain circuits for appetite
A two-in-one drug that modulates neural pathways involved in appetite and reward might prove to be more effective and longer lasting than current weight-loss drugs on the market.
- Tyler M. Cook
- & Darleen Sandoval
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News |
Experimental obesity drug packs double punch to reduce weight
Test of weight-loss candidate in mice shows that there is still room for improvement in a burgeoning field.
- Asher Mullard
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Article
| Open AccessGLP-1-directed NMDA receptor antagonism for obesity treatment
Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.
- Jonas Petersen
- , Mette Q. Ludwig
- & Christoffer Clemmensen
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Correspondence |
Interpersonal therapy can be an effective tool against the devastating effects of loneliness
- Myrna M. Weissman
- & Jennifer J. Mootz
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Outlook |
How ignorance and gender inequality thwart treatment of a widespread illness
Tens of millions of people have female genital schistosomiasis, a neglected tropical disease that few physicians have even heard of. Efforts are under way to move it out of obscurity and empower women and girls to access sexual and reproductive health care.
- Claire Ainsworth
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News |
Bird flu in US cows: where will it end?
Scientists worry that the H5N1 strain of avian influenza will become endemic in cattle, which would aid its spread in people.
- Sara Reardon
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Article
| Open AccessDiscovery of potent small-molecule inhibitors of lipoprotein(a) formation
Biochemical screening and optimization identify small molecules that inhibit the formation of lipoprotein(a), and these inhibitors reduce the levels of Lp(a) in several animal models, suggesting that they could provide a therapeutic option in humans.
- Nuria Diaz
- , Carlos Perez
- & Laura F. Michael
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Article |
A meta-analysis on global change drivers and the risk of infectious disease
Reducing greenhouse gas emissions, managing ecosystem health, and preventing biological invasions and biodiversity loss could help to reduce the burden of plant, animal and human diseases, especially when coupled with improvements to social and economic determinants of health.
- Michael B. Mahon
- , Alexandra Sack
- & Jason R. Rohr
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Nature Podcast |
Sex and gender discussions don't need to be toxic
The science of sex and gender is too often misinterpreted and weaponized. Now, three experts cut through the misinformation in search of a positive future for this long-neglected area of research
- Lucy Odling-Smee
- , Florence Ashley
- & Noah Baker
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Comment |
Male–female comparisons are powerful in biomedical research — don’t abandon them
Binary sex studies have been denounced as too simplistic, but dropping them altogether would impede progress in a long-neglected area of biomedicine.
- Arthur P. Arnold
- , Sabra L. Klein
- & Jeffrey S. Mogil
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News & Views |
Cells destroy donated mitochondria to build blood vessels
Organelles called mitochondria are transferred to blood-vessel-forming cells by support cells. Unexpectedly, these mitochondria are degraded, kick-starting the production of new ones and boosting vessel formation.
- Chantell S. Evans
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Article
| Open AccessMultimodal decoding of human liver regeneration
Harnessing single-nucleus RNA sequencing and spatial profiling, this work dissects unanticipated aspects of human liver regeneration to uncover a novel migratory hepatocyte subpopulation mediating wound closure following acute liver injury.
- K. P. Matchett
- , J. R. Wilson-Kanamori
- & N. C. Henderson
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Nature Podcast |
Audio long read: Why loneliness is bad for your health
New research is revealing the mechanisms linking loneliness and conditions like dementia, depression and cardiovascular disease.
- Saima May Sidik
- & Benjamin Thompson
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News & Views |
Targeting RNA opens therapeutic avenues for Timothy syndrome
A therapeutic strategy that alters gene expression in a rare and severe neurodevelopmental condition has been tested in stem-cell-based models of the disease, and has been shown to correct genetic and cellular defects.
- Silvia Velasco
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Article |
Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
VVD-133214, a clinical-stage, covalent allosteric inhibitor of the helicase WRN, was well tolerated in mice and led to robust tumour regression in multiple microsatellite-instability-high colorectal cancer cell lines and patient-derived xenograft models.
- Kristen A. Baltgalvis
- , Kelsey N. Lamb
- & Todd M. Kinsella
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Editorial |
Any plan to make smoking obsolete is the right step
The United Kingdom is correct to attempt to end the single largest preventable cause of illness and death, as was New Zealand before its government changed its mind.
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Spotlight |
Deadly diseases and inflatable suits: how I found my niche in virology research
Virologist Hulda Jónsdóttir studies some of the world’s most pathogenic viruses at the Spiez Laboratory in Switzerland.
- Nikki Forrester
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News Feature |
Obesity drugs aren’t always forever. What happens when you quit?
Many researchers think that Wegovy and Ozempic should be taken for life, but myriad factors can force people off them.
- McKenzie Prillaman
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News Feature |
The rise of eco-anxiety: scientists wake up to the mental-health toll of climate change
Researchers want to unpick how climate change affects mental health around the world — from lives that are disrupted by catastrophic weather to people who are anxious about the future.
- Helen Pearson
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Research Briefing |
Genetic risk variants lead to type 2 diabetes development through different pathways
The largest genome-wide association study for type 2 diabetes so far, which included several ancestry groups, led to the identification of eight clusters of genetic risk variants. The clusters capture different biological pathways that contribute to the disease, and some clusters are associated with vascular complications.
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Nature Podcast |
The ‘ghost roads’ driving tropical deforestation
Researchers find that a huge number of roads that don’t appear on official maps, and the protein that could determine whether someone is left-handed.
- Nick Petrić Howe
- & Benjamin Thompson
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