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Experimental obesity drug packs double punch to reduce weight

Test of weight-loss candidate in mice shows that there is still room for improvement in a burgeoning field.
  1. Asher Mullard
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With obesity drugs now helping people to slim down, researchers are working to capitalize on their popularity by bulking up the weight-loss drug pipeline. The latest contender takes a Trojan horse approach — hiding a small molecule in a gut-hormone-mimicking peptide already used in obesity drugs — to strike a double blow to the brain cells that control appetite.

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Nature 629, 733-734 (2024)

doi: https://doi.org/10.1038/d41586-024-01433-6

Read the related News & Views: ‘Obesity drug rewires brain circuits for appetite’

References

  1. Petersen, J. et al. Nature https://doi.org/10.1038/s41586-024-07419-8 (2024).

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  2. Locke, A. E. et al. Nature 518, 197–206 (2015).

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  3. Cook, T. M. & Sandoval, D. Nature https://doi.org/10.1038/d41586-024-01352-6 (2024).

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