Article
|
Open Access
Featured
-
-
News |
Move over, CRISPR: RNA-editing therapies pick up steam
Two RNA-editing therapies for genetic diseases have in the past few months gained approval for clinical trials, raising hopes for safer treatments.
- Mariana Lenharo
-
News |
Smoking scars the immune system for years after quitting
A cigarette habit and previous infection with a common virus both have important effects on the immune system.
- Heidi Ledford
-
Article |
Deep whole-genome analysis of 494 hepatocellular carcinomas
The Chinese Liver Cancer Atlas project depicts a panoramic genomic landscape of hepatocellular carcinoma, covering candidate coding and non-coding drivers, mutational signatures, extrachromosomal circular DNA, subclonal catastrophic events and detailed evolutionary history.
- Lei Chen
- , Chong Zhang
- & Hongyang Wang
-
News |
Early dementia diagnosis: blood proteins reveal at-risk people
The results of a large-scale screening study could be used to develop blood tests to diagnose diseases such as Alzheimer’s before symptoms take hold.
- Miryam Naddaf
-
Article
| Open AccessCirculating myeloid-derived MMP8 in stress susceptibility and depression
Serum MMP8 is increased in stress-susceptible mice following chronic stress and leads to brain structure and behavioural changes in mice.
- Flurin Cathomas
- , Hsiao-Yun Lin
- & Scott J. Russo
-
Article |
Convergence of coronary artery disease genes onto endothelial cell programs
Variant-to-gene-to-program is a new approach to building maps of genome function to link risk variants to disease genes and to convergent signalling pathways in an unbiased manner; its strength is demonstrated in coronary artery disease.
- Gavin R. Schnitzler
- , Helen Kang
- & Jesse M. Engreitz
-
Comment |
No ‘easy’ weight loss: don’t overlook the social cost of anti-obesity drugs
Ideas of diet and exercise as the ‘best’ way to lose weight could stigmatize people taking Ozempic, WeGovy and other blockbuster drugs that affect appetite. Lessons from weight-loss surgery reveal ways to help.
- Alexandra Brewis
- & Sarah Trainer
-
Article
| Open AccessMatrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
Structural changes mediated by advanced glycation end-products enhance extracellular matrix viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.
- Weiguo Fan
- , Kolade Adebowale
- & Natalie J. Török
-
News |
Signs of ‘transmissible’ Alzheimer’s seen in people who received growth hormone
The findings support a controversial hypothesis that proteins related to the neurodegenerative disease can be ‘seeded’ in the brain through material taken from cadavers.
- Carissa Wong
-
Nature Podcast |
Audio long read: Long COVID is a double curse in low-income nations — here’s why
A dearth of research means the condition is often ignored by physicians.
- Heidi Ledford
- & Benjamin Thompson
-
News |
Obesity drugs have another superpower: taming inflammation
The blockbuster medications that reduce body weight also reduce inflammation in organs such as the brain, raising hopes that they can treat Parkinson's and Alzheimer's diseases.
- Mariana Lenharo
-
Outlook |
Tracking down tuberculosis
Improvements in screening and diagnosis could help to eradicate this curable disease.
- Neil Savage
-
Article
| Open AccessRedefining the treponemal history through pre-Columbian genomes from Brazil
Reconstruction of four Treponema pallidum genomes associated with human remains from around 2,000 years ago suggests that T. pallidum existed in the Americas and diverged to its modern subspecies before the fifteenth century European contact with the Americas.
- Kerttu Majander
- , Marta Pla-Díaz
- & Verena J. Schuenemann
-
Article
| Open AccessThe HIV capsid mimics karyopherin engagement of FG-nucleoporins
Dissection of the nuclear pore complex provides a model in which the HIV capsid enters the nucleus through karyopherin mimicry, a mechanism likely to be conserved across other viruses.
- C. F. Dickson
- , S. Hertel
- & D. A. Jacques
-
Article
| Open AccessDeciphering cell states and genealogies of human haematopoiesis
An improved, single-cell lineage-tracing system, based on deep detection of naturally occurring mitochondrial DNA mutations with simultaneous readout of transcriptional states and chromatin accessibility, is used to define the clonal architecture of haematopoietic stem cells.
- Chen Weng
- , Fulong Yu
- & Vijay G. Sankaran
-
Article
| Open AccessAutoreactive T cells target peripheral nerves in Guillain–Barré syndrome
Autoreactive T cells that target myelin antigens in the peripheral nerves are present in patients with the demyelinating form of Guillain–Barré syndrome, and these T cells are likely to contribute to disease pathophysiology.
- L. Súkeníková
- , A. Mallone
- & D. Latorre
-
News Feature |
Chimpanzees are dying from our colds — these scientists are trying to save them
Humans are increasingly passing pathogens to animal populations, imperilling endangered species such as chimpanzees and gorillas.
- Rachel Nuwer
-
Outlook |
Yaws could soon be eradicated — 70 years behind schedule
Researchers are cautiously optimistic that the neglected tropical disease could be gone by 2030, but new barriers — including antibiotic resistance and primate reservoirs — might stand in the way.
- Sam Jones
-
News & Views |
Prehistoric events might explain European multiple sclerosis risk
An exploration of more than 1,600 ancient Eurasian genomes suggests that genetic changes that increase autoimmune-disease risk in modern Europeans could have protected ancient Europeans from pathogens.
- Samira Asgari
- & Lionel A. Pousaz
-
News |
Ancient DNA reveals origins of multiple sclerosis in Europe
A huge cache of ancient genomes spanning tens of thousands of years reveals the roots of traits in modern Europeans.
- Sara Reardon
-
Article
| Open AccessElevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
Analysis of a large ancient genome dataset shows that genetic risk for multiple sclerosis rose in steppe pastoralists, providing insight into how genetic ancestry from the Neolithic and Bronze Age has shaped modern immune responses.
- William Barrie
- , Yaoling Yang
- & Eske Willerslev
-
Comment |
Boosting microbiome science worldwide could save millions of children’s lives
Studies of the microbes living on and in our bodies are conducted mainly in a few rich countries, squandering opportunities to improve the health of people globally.
- Hilary P. Browne
- , Najeeha Talat Iqbal
- & Samuel Kariuki
-
News |
Potent psychedelic drug banishes PTSD, small study finds
Military veterans with cognitive and psychological problems saw drastic improvements after a dose of ibogaine.
- Max Kozlov
-
Editorial |
A new class of antibiotics is cause for cautious celebration — but the economics must be fixed
The threat of antimicrobial resistance means that new antibiotics need to be used sparingly. Governments must support their development with a long-term funding plan.
-
Research Briefing |
Small numbers of sodium channels on cartilage cells have a large effect on joint damage
A type of sodium channel previously thought to be specific to neurons is also present in chondrocytes — cells that are crucial for joint health. Despite having low density, the sodium channels have an outsized role in the progression of osteoarthritis, and their genetic deletion or pharmacological inhibition reduced joint damage in mouse models.
-
News Feature |
Long COVID is a double curse in low-income nations — here’s why
Not only is the prevalence of the condition poorly understood, but it’s also often ignored by physicians and the wider public.
- Heidi Ledford
-
Article
| Open AccessNav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
The voltage-gated sodium channel Nav1.7 has a dual role in osteoarthritis—in chondrocytes, it promotes joint damage, and in dorsal root ganglia neurons, it increases pain transmission.
- Wenyu Fu
- , Dmytro Vasylyev
- & Chuan-ju Liu
-
Article
| Open AccessDigital measurement of SARS-CoV-2 transmission risk from 7 million contacts
Digital measurements of proximity and duration of exposure by the NHS COVID-19 app show a strong relation to actual infections among 7 million contacts notified in England and Wales, with longer durations translating to increased risk of transmission.
- Luca Ferretti
- , Chris Wymant
- & Christophe Fraser
-
Correspondence |
Heal the aftermath of intergenerational trauma and grief
- Yafit Levin
- , Menachem Ben-Ezra
- & Yaira Hamama-Raz
-
News |
The science events to watch for in 2024
Advanced AI tools, Moon missions and ultrafast supercomputers are among the developments set to shape research in the coming year.
- Miryam Naddaf
-
Research Briefing |
What makes people with diabetes more susceptible to serious lung infections?
Diabetes is a strong risk factor for viral respiratory infections, including influenza and COVID-19, which can be particularly dangerous for people with the condition. The discovery that the metabolism of lung dendritic cells, key sentinels of the immune system, is disrupted by high blood-sugar levels could provide a route to reversing this susceptibility.
-
News & Views |
Nausea and vomiting in pregnancy linked to hormone from fetus
Maternal sensitivity to a hormone produced by the fetus might underlie the risk of severe nausea and vomiting in human pregnancy — a finding that could open up strategies for the treatment of this debilitating condition.
- Alice E. Hughes
- & Rachel M. Freathy
-
Nature Podcast |
Cat parasite Toxoplasma tricked to grow in a dish
Cat-only life-cycle stage cultured in vitro, and the mysterious giant proteins that might turn bacteria into killers.
- Nick Petrić Howe
- & Shamini Bundell
-
News Feature |
Weight-loss-drug pioneer: this biochemist finally gained recognition for her work
Svetlana Mojsov led early studies of GLP-1, the hormone behind Wegovy, Ozempic and other blockbusters.
- Elie Dolgin
-
News Feature |
Malaria fighter: this researcher paved the way for a game-changing vaccine
Halidou Tinto runs a clinic in rural Burkina Faso that has been instrumental to the approval of the world’s first malaria vaccines.
- Brendan Maher
-
Article
| Open AccessLung dendritic-cell metabolism underlies susceptibility to viral infection in diabetes
Hyperglycaemia leads to impaired costimulatory molecule expression, antigen transport and T cell priming in distinct lung dendritic cell subsets, driving a defective antiviral adaptive immune response, delayed viral clearance and enhanced mortality.
- Samuel Philip Nobs
- , Aleksandra A. Kolodziejczyk
- & Eran Elinav
-
Article
| Open AccessGDF15 linked to maternal risk of nausea and vomiting during pregnancy
Elevated circulating levels of GDF15 in pregnant women are associated with severe nausea and vomiting, and sensitivity to such symptoms during pregnancy is partly determined by prepregnancy levels of this hormone.
- M. Fejzo
- , N. Rocha
- & S. O’Rahilly
-
Article |
Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling
The potential use of circulating tumour DNA in classic Hodgkin lymphoma detection, classification and monitoring is defined.
- Stefan K. Alig
- , Mohammad Shahrokh Esfahani
- & Ash A. Alizadeh
-
News |
Are your organs ageing well? The blood holds clues
One organ in a person’s body can age faster than the rest — with implications for health and mortality.
- Max Kozlov
-
Article
| Open AccessReverse metabolomics for the discovery of chemical structures from humans
A new discovery strategy, ‘reverse metabolomics’, facilitates high-throughput matching of mass spectrometry spectra in public untargeted metabolomics datasets, and a proof-of-concept experiment identified an association between microbial bile amidates and inflammatory bowel disease.
- Emily C. Gentry
- , Stephanie L. Collins
- & Pieter C. Dorrestein
-
News Explainer |
Climate change is also a health crisis — these 3 graphics explain why
Health is on the agenda at the COP28 climate meeting. Rising temperatures increase the spread of infectious diseases, claim lives and drive food insecurity.
- Carissa Wong
-
News Explainer |
Why has swine flu emerged in a person in the UK — and what’s next?
Scientists are closely monitoring a virus that has been detected for the first time in a UK individual.
- Katharine Sanderson
-
Outlook |
Putting low-cost diagnostics to the test
The COVID-19 pandemic brought home the value of cheap, ‘good enough’ methods of detecting disease. Extending that approach to other illnesses could improve health care in low- and middle-income countries.
- Michael Eisenstein
-
Nature Podcast |
Polio could be eradicated within 3 years — what happens then?
How to ensure polio doesn’t return after eradication, and the space explosion that’s baffling scientists.
- Benjamin Thompson
- & Shamini Bundell
-
Article |
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease
A large fraction of patients with APS-1 and coeliac disease develop enamel dystrophy, characterized by the presence of autoantibodies against the enamel matrix, which are generated through the breakdown of either central (APS-1) or peripheral (coeliac) tolerance to a battery of ameloblast-sepecific proteins.
- Yael Gruper
- , Anette S. B. Wolff
- & Jakub Abramson
-
-
World View |
Only 0.5% of neuroscience studies look at women’s health. Here’s how to change that
A new initiative challenges the severe neglect of women’s brain health from puberty through to pregnancy and menopause.
- Emily G. Jacobs
-
News |
Massive genetic study finds genes linked to cannabis addiction
Data from more than one million genomes offer fresh insights into excessive cannabis use and its relationship to other diseases.
- Lilly Tozer
-
News Explainer |
How wild monkeys ‘laundered’ for science could undermine research
Demand is fuelling an illegal trade. But smuggled monkeys carry diseases that can disrupt experiments and lead to unreliable data.
- Gemma Conroy
Browse broader subjects
Browse narrower subjects
- Cancer
- Cardiovascular diseases
- Dental diseases
- Endocrine system and metabolic diseases
- Eye diseases
- Gastrointestinal diseases
- Haematological diseases
- Immunological disorders
- Infectious diseases
- Kidney diseases
- Metabolic disorders
- Neurological disorders
- Nutrition disorders
- Oral diseases
- Psychiatric disorders
- Reproductive disorders
- Respiratory tract diseases
- Rheumatic diseases
- Skin diseases
- Trauma
- Urogenital diseases