Featured
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Article |
A tissue-like neurotransmitter sensor for the brain and gut
NeuroString, a tissue-like biological interface created by laser patterning of polyimide into a graphene/nanoparticle network embedded in an elastomer, is introduced, allowing in vivo real-time detection of neurotransmitters in the brain and gut.
- Jinxing Li
- , Yuxin Liu
- & Zhenan Bao
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News Explainer |
Why call it BA.2.12.1? A guide to the tangled Omicron family
Nature explores how subvariants are named, and why none of Omicron’s family members has been upgraded to a ‘variant of concern’.
- Amy Maxmen
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Nature Video |
Lasers reveal ancient pyramids and canals hidden in the Amazon
Hundreds of new archaeological sites have been discovered beneath the trees.
- Shamini Bundell
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Correspondence |
Africa needs more bioinformaticians for population studies
- Ashraf Akintayo Akintola
- , Ui Wook Hwang
- & Abdullahi Tunde Aborode
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News & Views |
From the archive: Jamaican coral reefs, and indispensable photography
Snippets from Nature’s past.
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Technology Feature |
The overlooked variable in animal studies: why diet makes a difference
Careful consideration and documentation of laboratory animals’ diets will boost the reproducibility of experiments.
- Jyoti Madhusoodanan
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News |
Gene-edited tomatoes could provide new source of vitamin D
Plants rich in a precursor to the vitamin could help to address deficiencies — but face a long road to market.
- Heidi Ledford
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Article |
Microfluidic chain reaction of structurally programmed capillary flow events
Microfluidic chain reactions encode programs structurally in situ, and can form a frugal, versatile, bona fide lab-on-a-chip with wide-ranging applications in liquid handling and point-of-care diagnostics
- Mohamed Yafia
- , Oriol Ymbern
- & David Juncker
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Article |
Mitochondrial base editor induces substantial nuclear off-target mutations
- Zhixin Lei
- , Haowei Meng
- & Chengqi Yi
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Article |
Transcriptional coupling of distant regulatory genes in living embryos
In Drosophila, there are extensive physical and functional associations of distant paralogous genes, including co-regulation by shared enhancers and co-transcriptional initiation over distances of nearly 250 kilobases.
- Michal Levo
- , João Raimundo
- & Michael S. Levine
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Technology Feature |
Base edit your way to better crops
Plant scientists are turning to genome-editing techniques to precisely tailor the productivity and consumer appeal of important crops.
- Michael Eisenstein
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News |
China focuses on ethics to deter another ‘CRISPR babies’ scandal
But some question whether a statement from the government will deter scientists from carrying out research that violates ethical norms.
- Smriti Mallapaty
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Perspective |
The Human Pangenome Project: a global resource to map genomic diversity
The Human Pangenome Reference Consortium aims to offer the highest quality and most complete human pangenome reference that provides diverse genomic representation across human populations.
- Ting Wang
- , Lucinda Antonacci-Fulton
- & David Haussler
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News Feature |
What's next for AlphaFold and the AI protein-folding revolution
DeepMind software that can predict the 3D shape of proteins is already changing biology.
- Ewen Callaway
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News & Views |
Democratizing the mapping of gene mutations to protein biophysics
A general method that quantifies and disentangles the effects of a gene’s mutations on the traits of its protein enables assessments of mutational effects on protein biophysics for many of the proteins of a living organism.
- Debora S. Marks
- & Stephen W. Michnick
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News |
Your brain expands and shrinks over time — these charts show how
Based on more than 120,000 brain scans, the charts are still preliminary. But researchers hope they could one day be used as a routine clinical tool by physicians.
- Max Kozlov
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Article |
Mapping the energetic and allosteric landscapes of protein binding domains
An approach that combines deep mutational scanning with neural network-based thermodynamic modelling is used to provide comprehensive maps of the energetic and allosteric effects of mutations in two common protein domains.
- Andre J. Faure
- , Júlia Domingo
- & Ben Lehner
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Article
| Open AccessCapturing a rhodopsin receptor signalling cascade across a native membrane
The rhodopsin signalling cascade, initiated by light, is captured using mass spectrometry of a native membrane.
- Siyun Chen
- , Tamar Getter
- & Carol V. Robinson
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Article
| Open AccessDesign of protein-binding proteins from the target structure alone
A design pipeline is presented whereby binding proteins can be designed de novo without the need for prior information on binding hotspots or fragments from structures of complexes with binding partners.
- Longxing Cao
- , Brian Coventry
- & David Baker
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Correspondence |
Secure molybdenum isotope supplies for diagnostics
- Antonino Pietropaolo
- , Marco Capogni
- & Lina Quintieri
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News |
Major CRISPR patent decision won’t end tangled dispute
Fights over who invented the gene-editing technology are becoming more complex, and could carry on for years.
- Heidi Ledford
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Article |
Regulation of liver subcellular architecture controls metabolic homeostasis
Detailed reconstruction using enhanced focused ion beam scanning electron microscopy imaging and deep-learning-based automated segmentation demonstrates that hepatocyte subcellular organelle architecture regulates metabolism.
- Güneş Parlakgül
- , Ana Paula Arruda
- & Gökhan S. Hotamışlıgil
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Where I Work |
Staring into the human genome to diagnose COVID
Bioinformatician Lucía Spangenberg is helping to make genetic sequencing available to anyone who needs it.
- Patricia Maia Noronha
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Article
| Open AccessStructural basis for mismatch surveillance by CRISPR–Cas9
Cryo-electron microscopy structures of Cas9 during mismatch cleavage provide insight into the mechanisms that control off-target effects of Cas9, which will aid in the future design of high-fidelity Cas9 variants with reduced off-target cleavage.
- Jack P. K. Bravo
- , Mu-Sen Liu
- & David W. Taylor
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News |
How to protect the first ‘CRISPR babies’ prompts ethical debate
Fears of excessive interference cloud proposal for protecting children whose genomes were edited, as He Jiankui’s release from jail looks imminent.
- Smriti Mallapaty
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Where I Work |
Gut feeling: building a picture of Latin American microbiomes
Computational microbiologist Gregorio Iraola leads a consortium focused on tailoring public-health interventions for local needs.
- Jack Leeming
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Research Highlight |
Soft X-rays capture the dance of the organelles
A CT-like scan images what’s inside a live cell in 3D — including the interactions of its components.
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News |
China’s approval of gene-edited crops energizes researchers
Scientists say newly published guidelines will spur research into crops that have increased yields and greater resilience to climate change.
- Smriti Mallapaty
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News & Views |
From the archive
Nature’s pages feature the discovery of a key defence response, and a collection of items from an inventor highlights developments in photography.
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Technology Feature |
Seven technologies to watch in 2022
Our fifth annual round-up of the tools that look set to shake up science this year.
- Michael Eisenstein
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Research Highlight |
Synthetic viral lookalikes sneak gene-editing tools into cells
Specially engineered particles allow researchers to fix blindness-causing genes in mice.
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Nature Podcast |
Audio long-read: The secret lives of cells — as never seen before
Imaging techniques are revealing unprecedented details about the inner workings of cells.
- Diana Kwon
- & Benjamin Thompson
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Article
| Open AccessOmicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
A high-throughput yeast display platform is used to analyse the profiles of mutations in the SARS-CoV-2 receptor-binding domain (RBD) that enable escape from antibodies, and suggests that most anti-RBD antibodies can be escaped by the Omicron variant.
- Yunlong Cao
- , Jing Wang
- & Xiaoliang Sunney Xie
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News & Views |
Low-power light modifies electron microscopy
An optical device designed to control the properties of electron waves inside an electron microscope demonstrates that clever platforms for integrated photonics need not be powered by expensive laser systems.
- Martin Kozák
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Technology Feature |
Embryo-like models shed fresh light on early human development
A wave of stem-cell systems are enabling researchers to unpick what happens after an embryo implants in the uterus.
- Sandeep Ravindran
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Article |
Spatial genomics enables multi-modal study of clonal heterogeneity in tissues
A technique using barcoded beads for DNA sequencing within tissue sections enables spatial resolution of tumour clonal heterogeneity and can be multiplexed with other analytical techniques for analysis of complex cellular phenotypes.
- Tongtong Zhao
- , Zachary D. Chiang
- & Fei Chen
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Research Highlight |
Nervous stomach: lab-grown organs clench like the real thing
The most complex stomach organoids yet are made with cells from three layers found in developing embryos.
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Technology Feature |
Python power-up: new image tool visualizes complex data
The image viewing and analysis software napari has filled a gap in the programming language’s scientific ecosystem.
- Jeffrey M. Perkel
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Article |
Multiview confocal super-resolution microscopy
A combination of multiview imaging, structured illumination, reconstruction algorithms and deep-learning predictions realizes spatial- and temporal-resolution improvements in fluorescence microscopy to produce super-resolution images from diffraction-limited input images.
- Yicong Wu
- , Xiaofei Han
- & Hari Shroff
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Technology Feature |
Artificial intelligence powers protein-folding predictions
Deep-learning algorithms such as AlphaFold2 and RoseTTAFold can now predict a protein’s 3D shape from its linear sequence — a huge boon to structural biologists.
- Michael Eisenstein
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Research Highlight |
Brightest X-rays on Earth expose COVID lung damage
Imaging technique can pick up micrometre-scale details of intact brains and other organs.
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Article
| Open AccessA chickpea genetic variation map based on the sequencing of 3,366 genomes
Whole-genome sequencing of 3,171 cultivated and 195 wild chickpea accessions is used to construct a chickpea pan-genome, providing insight into chickpea evolution and enabling breeding strategies that could improve crop productivity.
- Rajeev K. Varshney
- , Manish Roorkiwal
- & Xin Liu
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Technology Feature |
An expanding molecular toolbox untangles neural circuits
Scientists are developing ways to probe the activity, function and organization of neurons in real time with increasing precision.
- Esther Landhuis
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Article |
Striatal indirect pathway mediates exploration via collicular competition
Indirect striatal projection neurons in the basal ganglia modulate activity in the superior colliculus, thereby controlling selection and exploration of actions in response to a reward omission.
- Jaeeon Lee
- & Bernardo L. Sabatini
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News & Views |
From the archive
Nature’s pages feature efforts to ensure thermometer accuracy and offer some gardening advice.
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Technology Feature |
Refining the toolkit for sugar analysis
Antibodies and other reagents for glycans have lagged behind those for proteins and nucleic acids, but the field is catching up.
- Amber Dance
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Article |
AKIRIN2 controls the nuclear import of proteasomes in vertebrates
Using time-controlled CRISPR screens, the authors identify AKIRIN2 as a factor involved in the nuclear import of the proteasome.
- Melanie de Almeida
- , Matthias Hinterndorfer
- & Johannes Zuber
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Outlook |
Optics shine a light on dental imaging
Light can outperform X-rays in tooth examinations and avoids the use of ionizing radiation.
- Neil Savage
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News Feature |
The secret lives of cells — as never seen before
Cutting-edge microscopy techniques are allowing researchers to spy on the innards of cells in all their crowded glory.
- Diana Kwon
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