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Open Access
Featured
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Book Review |
Anna Atkins: pioneering botanical photographer who captured algae and ferns in ghostly blue images
A compilation of 550 original plates reveals the dedicated work of the nineteenth-century woman who was the first to publish a book with cyanotypes of specimens.
- Georgina Ferry
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News |
AI search of Neanderthal proteins resurrects ‘extinct’ antibiotics
Scientists identify protein snippets made by extinct hominins.
- Saima Sidik
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Article
| Open AccessMega-scale experimental analysis of protein folding stability in biology and design
Large-scale assays using cDNA display proteolysis are used to measure the folding stabilities of protein domains, providing a method to quantify the effects of mutations on protein folding, with applications in protein design.
- Kotaro Tsuboyama
- , Justas Dauparas
- & Gabriel J. Rocklin
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Article |
High-throughput Oligopaint screen identifies druggable 3D genome regulators
High-throughput DNA or RNA labelling with optimized Oligopaints (HiDRO) reveals more than 300 factors that influence genome folding during interphase, including 43 genes that were validated as either increasing or decreasing interactions between topologically associating domains.
- Daniel S. Park
- , Son C. Nguyen
- & Eric F. Joyce
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News |
Developing human embryos imaged at highest-ever resolution
Non-invasive imaging approach could lead to innovations in embryo screening.
- Miryam Naddaf
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Article
| Open AccessEvolution of a minimal cell
An engineered minimal cell evolves to escape the negative consequences of genome streamlining.
- R. Z. Moger-Reischer
- , J. I. Glass
- & J. T. Lennon
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Outlook |
How genetically modified mosquitoes could eradicate malaria
Gene-drive technology that can spread antimalarial modifications throughout mosquito populations is maturing, but there are questions to answer before it can be used in the wild.
- Sam Jones
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News |
Ancient-DNA researcher fired for ‘serious misconduct’ lands new role
Former co-workers have expressed shock that Charles Sturt University in southeastern Australia has appointed Alan Cooper to its faculty.
- Dyani Lewis
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Article |
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
BAC stepwise insertion synthesis (BASIS) can be used to build synthetic genomes for diverse organisms, and continuous genome synthesis (CGS) enables the rapid synthesis of entire Escherichia coli genomes from functional designs.
- Jérôme F. Zürcher
- , Askar A. Kleefeldt
- & Jason W. Chin
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Article |
A spatially resolved single-cell genomic atlas of the adult human breast
The Human Breast Cell Atlas identifies 12 major breast cell types and 58 biological cell states, revealing abundant pericyte, endothelial and immune cell populations, and highly diverse luminal epithelial cell states.
- Tapsi Kumar
- , Kevin Nee
- & Nicholas Navin
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Article
| Open AccessSingle-cell quantification of ribosome occupancy in early mouse development
A single-cell ribosome profiling method can provide data at the level of allele-specific ribosome engagement in early development.
- Hakan Ozadam
- , Tori Tonn
- & Can Cenik
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Article
| Open AccessA pangenome reference of 36 Chinese populations
A study reports data from the first phase of the Chinese Pangenome Consortium including 116 de novo assemblies from 58 core samples representing 36 minority Chinese ethnic groups.
- Yang Gao
- , Xiaofei Yang
- & Shuhua Xu
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Article |
Genome editing of a rice CDP-DAG synthase confers multipathogen resistance
Editing of a rice gene that has a role in phospholipid synthesis has endowed rice plants with broad-spectrum resistance to disease, including protection from common bacterial and fungal pathogens, without decreasing the yield.
- Gan Sha
- , Peng Sun
- & Guotian Li
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Technology Feature |
Powerful microscope captures motor proteins in unprecedented detail
Called MINFLUX, the super-resolution method allows researchers to track molecules under cellular conditions.
- Amanda Heidt
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Article |
Hydration solids
A study shows that water can control macroscopic properties of biological materials through the hydration force, giving rise to a distinct class of solid matter with unusual properties.
- Steven G. Harrellson
- , Michael S. DeLay
- & Ozgur Sahin
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Article
| Open AccessUltraviolet radiation shapes dendritic cell leukaemia transformation in the skin
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arises from clonal (premalignant) haematopoietic precursors in the bone marrow, and BPDCN skin tumours first develop at sun-exposed anatomical sites and are distinguished by clonally expanded mutations induced by ultraviolet radiation.
- Gabriel K. Griffin
- , Christopher A. G. Booth
- & Andrew A. Lane
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Article |
Indefinite and bidirectional near-infrared nanocrystal photoswitching
This study reports unlimited near-infrared photoswitching in inorganic avalanching nanoparticles via a discrete shift of threshold intensity mediated by internal defect-based colour centres.
- Changhwan Lee
- , Emma Z. Xu
- & P. James Schuck
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Correspondence |
Satellite imagery identifies deliberate attacks on hospitals
- Danielle N. Poole
- , Nathaniel A. Raymond
- & Kaveh Khoshnood
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News & Views |
Cocktails of tags enhance resolution of microscopy technique
A limit on the resolution of optical-microscopy techniques has been broken by using a mixture of tags to label copies of target molecules in a sample, opening the way to better views of molecular organization in cells.
- Alistair Curd
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Outlook |
Revealing vascular roadblocks in the brain
High-resolution imaging quickly identifies blood clots before they inflict major damage.
- Michael Eisenstein
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Article
| Open AccessÅngström-resolution fluorescence microscopy
The authors introduce a single-molecule DNA-barcoding method, resolution enhancement by sequential imaging, that improves the resolution of fluorescence microscopy down to the Ångström scale using off-the-shelf fluorescence microscopy hardware and reagents.
- Susanne C. M. Reinhardt
- , Luciano A. Masullo
- & Ralf Jungmann
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Editorial |
For chemists, the AI revolution has yet to happen
Machine-learning systems in chemistry need accurate and accessible training data. Until they get it, they won’t achieve their potential.
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Article
| Open AccessStructural basis of NINJ1-mediated plasma membrane rupture in cell death
Structural, biochemical and mutagenesis studies indicate that, in dying cells, the membrane protein NINJ1 assembles into filaments, disrupting the cell membrane.
- Morris Degen
- , José Carlos Santos
- & Sebastian Hiller
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News |
Deadly mushroom poison might now have an antidote — with help from CRISPR
Gene-editing technique might have finally cracked the mystery of how death cap mushrooms kill.
- Saima Sidik
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Technology Feature |
Brain imaging: fMRI advances make scans sharper and faster
Researchers are finding ways to improve one of neuroscientists’ favourite tools: functional magnetic resonance imaging.
- Diana Kwon
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News |
Lab-grown monkey embryos reveal in 3D how organs begin
At 25 days old, specimens could be the oldest primate embryos ever grown outside the womb.
- Gemma Conroy
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Research Briefing |
Detectors that encode angles of incoming light as colour
Most light-field sensors — devices that detect the angles of incoming light rays to reconstruct 3D scenes — can detect light only in the ultraviolet and visible wavelength ranges. A newly developed light-field sensor comprising perovskite nanocrystals encodes the angles of incoming visible-light beams and X-rays as different colours.
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Nature Podcast |
‘Pangenome’ aims to capture the breadth of human diversity
Mapping a more diverse human genome, and the latest from the Nature Briefing.
- Nick Petrić Howe
- & Shamini Bundell
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News |
New cellular ‘organelle’ discovered inside fruit-fly intestines
Fruit-fly cells use previously unknown complex cellular structures to store phosphate, a molecule essential to life
- Gemma Conroy
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News |
Huge cache of mammal genomes offers fresh insights on human evolution
The Zoonomia Project is helping to pinpoint genes responsible for animal-brain size and for human disease.
- Max Kozlov
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Editorial |
The gene-therapy revolution risks stalling if we don’t talk about drug pricing
Regulation and new intellectual property laws are needed to reduce the cost of gene-editing treatments and fulfil their promise to improve human health.
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News |
Comb jellies’ unique fused neurons challenge evolution ideas
Fused neurons suggest ctenophores’ nervous system evolved independently of that in other animals.
- Mariana Lenharo
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Technology Feature |
Every base everywhere all at once: pangenomics comes of age
Multi-genome assemblies called pangenomes can capture genetic diversity in a species, but researchers are still working out how best to build and explore them.
- Michael Eisenstein
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News |
‘Democracy in microscopy’: cheap light microscope delivers super-resolution images
Technique pushes the instruments to beat the resolving power of multi-million-dollar machines.
- Ewen Callaway
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Nature Video |
‘Touch-taste’: how the octopus repurposed its nervous system to hunt
Researchers identify the structural basis for octopuses chemo-tactile sense.
- Dan Fox
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Article
| Open AccessAstrocyte–neuron subproteomes and obsessive–compulsive disorder mechanisms
Analyses of the proteomes of astrocytes and neurons in a cell-specific and subcompartment-specific manner reveal distinct roles for these cell types that are relevant to obsessive–compulsive disorder and perhaps other brain disorders.
- Joselyn S. Soto
- , Yasaman Jami-Alahmadi
- & Baljit S. Khakh
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Obituary |
Paul Berg (1926–2023)
Biochemist who invented recombinant DNA technology.
- Errol Friedberg
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News & Views |
Eggs made from male mouse stem cells using error-prone culture
A screen of mouse stem cells that exploits their propensity to gain or lose chromosomes in cell culture has been used to convert male XY to female XX cells. Subsequent differentiation generates functional eggs and live offspring.
- Jonathan Bayerl
- & Diana J. Laird
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Research Briefing |
Diversity of mitochondrial networks in lung cancer imaged
The structure and function of mitochondrial networks were analysed using a combination of approaches to generate detailed maps of these cellular organelles. This analysis revealed that the mitochondria in different subtypes of lung cancer show distinct functional and structural signatures.
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Article
| Open AccessSpatial epigenome–transcriptome co-profiling of mammalian tissues
The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.
- Di Zhang
- , Yanxiang Deng
- & Rong Fan
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Article
| Open AccessFast and sensitive GCaMP calcium indicators for imaging neural populations
Using large-scale screening and structure-guided mutagenesis, fast and sensitive GCaMP sensors are developed and optimized with improved kinetics without compromising sensitivity or brightness.
- Yan Zhang
- , Márton Rózsa
- & Loren L. Looger
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News |
Why CRISPR babies are still too risky — embryo studies highlight challenges
While society grapples with the social and ethical implications of heritable genome editing, technical obstacles still abound.
- Heidi Ledford
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News |
Was famed poet Pablo Neruda poisoned? Scientists warn case not closed
Forensic investigation uncovers evidence that a lethal bacterium could have been in his body when he died.
- Michele Catanzaro
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Nature Podcast |
A twisting microscope that could unlock the secrets of 2D materials
How the Quantum Twisting Microscope could give a better ‘picture’ of atom thin layers, and science in Ukraine a year into Russia’s invasion.
- Shamini Bundell
- & Benjamin Thompson
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Article
| Open AccessDe novo design of luciferases using deep learning
A deep-learning-based strategy is used to design artificial luciferases that catalyse the oxidative chemiluminescence of diphenylterazine with high substrate specificity and catalytic efficiency.
- Andy Hsien-Wei Yeh
- , Christoffer Norn
- & David Baker
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News & Views |
From the archive: machine intelligence, and the father of X-rays
Snippets from Nature’s past.
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Technology Feature |
Innovative technologies crowd the short-read sequencing market
With a dizzying range of strategies available, laboratories must weigh up their options to find the best fit for their projects
- Michael Eisenstein
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Nature Podcast |
How ‘metadevices’ could make electronics faster
Getting electronics into super-fast terahertz speeds, and how cognitive changes could alter social media’s effects on young people.
- Nick Petrić Howe
- & Shamini Bundell
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News |
Disgraced CRISPR-baby scientist’s ‘publicity stunt’ frustrates researchers
He Jiankui refused to answer researchers’ questions about his controversial 2018 experiments at weekend event.
- Smriti Mallapaty
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