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This perspective describes how insects, such as Hermetia illucens, which are already used to process organic wastes at industrial scales, could be developed as a synthetic biology platform for sustainable biomanufacturing and bioremediation.
This Perspective discusses DNA-loop extrusion generated by SMC. The model details how the “DNA baton” is transferred from the hinge domain to a DNA pocket through anisotropic hinge motion, ensuring loop stability and providing insights into the dynamic process of DNA-loop extrusion.
Authors discuss big bottlenecks that inhibit vascular regeneration in the disease context of aortic aneurysm, stroke, and peripheral artery disease, along with emerging opportunities to overcome these challenges.
This perspective highlights the limitations of empirically evaluating causal gene discovery methods in the absence of completely labeled reference gene sets. It shows that sensitivity, specificity, and AUC may be critically biased, and advocate for increased reliance on probabilistic modeling.
Mammalian reproduction hinges on maternal-fetal communication mediated by extracellular vesicles. Their role in diagnostics and therapeutics shows promise, but questions about uptake, cargo delivery, and specific biomolecules remain.
A Mini Review summarizing the current understanding of epithelial-mesenchymal transition (EMT) and 3D genome organization, focusing on the role of chromatin conformation and accessibility changes during the transitional phases of EMT.
This perspective discusses five conservation challenges using a landscape in Ethiopia as the lens, exploring a story on how the ecology and evolution of coffee shape biodiversity conservation can inspire to view other landscapes with fresh eyes.
This article explores novel routes to better analyze neural processes underlying the brain’s adaptability and cognitive functioning, focusing on executive functions and cognitive control. It delves into the concept of “metacontrol”, proposing a dynamic balance of processes based on situational demands, and discusses the role of different concepts of neural dynamics in supporting adaptive behavior and understanding psychiatric disorders.
This review discusses recent advances demonstrating the role of replication stress as an ultimate driver of cellular senescence and aging, highlighting connections to hallmarks of aging, hereditary accelerated aging disorders, and senotherapeutics.
A review synthesizes interplays between photoperiodism and circadian regulation of the vegetative to reproductive transition in Arabidopsis and crops in responses to changing day lengths that ensures optimal timing for flowering and seed production.
Nucleic acids-based drugs aim to fix the genetic problem at its source and emerge as a promising new class of drugs. Recent advances in this field enabled their approval for the treatment of orphan genetic diseases for which no cure was available.
Presenting mechanisms that modulate cerebral vessel tone as interaction graphs to support research design, interpret study findings, and generate hypotheses on disease.
A review summarizes how ATG7 is precisely programmed by genetic, transcriptional, and epigenetic modifications in cells and its functions, including the relationship between ATG7 and aging-related diseases.
A Perspective on how the tools of behavioral science and the emerging field of diverse intelligence help to understand decision-making of cellular collectives in evolutionary and biomedical contexts.
This review introduces the basic principle of fluorescence and two-photon excitation microscopy that is aimed at novice and advanced microscopists highlighting current techniques, trends, and practical guides for live imaging optimization.
The snake venom toxins responsible for tissue damage, their mechanisms of action and pathological effects are reviewed, together with the search of novel therapeutic alternatives to abrogate their effects
A theoretical framework, the Multi-Dimensional Management of Multiple Pests, is proposed to enhance the adoption of green Integrated Pest Management (IPM) tactics and encourage a more comprehensive assessment of environmental benefits.