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A Hi-C study reveals the dynamic chromatin architecture of breast muscle and gene expression affected by breed-specific 3D genome architecture that may influence muscle growth and intramuscular fat deposition between fast-growing and slow-growing chickens.
The authors show that diubiquitin-derived artificial binding proteins (Affilin molecules) targeting oncofetal fibronectin employ β-strand register shifts in the scaffold, remodelling the binding interface to confer target affinity.
Cryo-EM analysis of fibrils from four cardiomyopathic ATTRwt amyloidosis patients reveals identical structures with minimal variability. This finding contributes to the understanding of ATTR amyloidosis biopathology.
Sexual dimorphism reflects divergent requirements between the sexes. We explore gene expression between two fireflies that show mild and extreme dimorphism. We uncover conserved and divergent gene expression, including complete dosage compensation.
Advanced fMRI, including the Functionnectome framework, reveals that visual consciousness arises from complex neural interactions, involving the superior longitudinal fasciculus, temporo-parietal fibers, the corpus callosum, and thalamic radiations
A structural study shows that the enzyme βPGM uses an allomorphically controlled switch that accelerates proline isomerisation to alleviate the wastage of valuable metabolites while allowing the organism to react quickly to changes in food supply.
This study looked for DNA methylation patterns in blood samples and its association with brain DNA methylation for neurodegenerative diseases. The findings suggest that DNA derived from blood can be used for biomarker discovery in these diseases.
Duck breeds selectively bred for disparate body shapes are found to walk with different limb kinematics but incur similar energetic costs. This is attributed to the interplay of dynamic kinematic and modular anatomical processes.
A high-content screening using a fluorescence readout has been used to identify pharmacological correctors of intracellularly-retained ABCB4 variants. The identified small molecules rescued canalicular targeting of ABCB4 variants.
The authors show that the transcription factors IRF8 and MAFB differentially alter the gene expression profiles of different resident macrophages, which might contribute to their functional diversity within the central nervous system.
This study explores the role of nuclear factor interleukin 3 (Nfil3) in metabolic dysfunction-associated fatty liver disease (MASLD) development, revealing sex-specific effects and gut microbiota influence on bile acid metabolism.
Six WWE domain-containing proteins also contain domains with E3 ubiquitin ligase activity. We report structures, biophysical and biochemical assays for the discovery of novel WWE domain binders and their respective application.
A draft genome and tissue-specific transcriptome assemblies of the large-polyp coral, Fimbriaphyllia ancora were established. This dataset and new insights into tissue functions will facilitate a deeper understanding of coral biology.
The study explores the activation mechanism of Staphylococcus aureus signal peptidase IB by the antibiotic PK150. We identified that PK150 shields the active site from excess water and stabilizes its catalytic geometry, thus enhancing catalysis.
Using comparative genomics, the authors unveil constrained evolutionary paths both at genomic and molecular levels during convergent evolution of two distinct lactic acid bacteria lineages.
The PCA pathway, essential for synthesizing CoA and AcCoA from vitamin B5, plays a crucial role in fungal cellular processes. Targeting this pathway could enhance antifungal drug efficacy by affecting vacuolar morphology and drug detoxification.
A study using electrophysiology, behavioral methods and modelling demonstrates the importance of the ventral pallidum and mediodorsal thalamus in DMN regulation in tree shrews.
HIF-1α plays an important role in bone homeostasis by upregulating Twist2 to suppress RUNX2 and regulate osteoblast differentiation, while also influencing osteoclast formation by regulating RANKL secretion through HIF-2a.
A study of intersexual mosquito males produced by hybridization between Aedes aegypti and Ae. mascarensis identified disruption of the sex determination pathway.