Extended Data Fig. 6: Long-term, repeatable cell-type specific neuromodulation for modulating intake and fat mass in HFD obese mice.
From: In vivo magnetogenetics for cell-type-specific targeting and modulation of brain circuits
(a) Statistical analysis of total food intake after long-term MMG stimulation in Vglut2 HFD mice. Food intakes are measured daily. One-way ANOVA with multiple comparison test; F(3, 16) = 4.619, p = 0.0164. Data are mean ± s.d. **p = 0.0045, **p = 0.0049; two-tailed unpaired Student’s t-test; n = 5 (Piezo1-m-Torquer-), 4 (Piezo1-m-Torquer + ), 5 (Piezo1+m-Torquer-) and 6 (Piezo1+m-Torquer + ) animals, respectively. (b) Statistical analysis of total food intake after long-term MMG stimulation in Vgat HFD mice. Food intakes are measured daily. One-way ANOVA with multiple comparison test; F(3, 12) = 8.523, p = 0.0027. Data are mean ± s.d. *p = 0.0220, **p = 0.0022; two-tailed unpaired Student’s t-test; n = 3 (Piezo1-m-Torquer-), 3 (Piezo1-m-Torquer + ), 5 (Piezo1+m-Torquer-) and 5 (Piezo1+m-Torquer + ) animals, respectively. (c, d) Photographs of white adipose tissues acquired from (c) Vglut2 HFD mice and (d) Vgat HFD mice. Scale bars in (c, d), 1 cm.