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UDP-N-acetylgalactosamine diphosphorylase

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UDP-N-acetylgalactosamine diphosphorylase
Identifiers
EC no.2.7.7.83
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

UDP-N-acetylgalactosamine diphosphorylase (EC 2.7.7.83) is an enzyme with systematic name UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase.[1][2] This enzyme catalyses the following chemical reaction

UTP + N-acetyl-alpha-D-galactosamine 1-phosphate diphosphate + UDP-N-acetyl-alpha-D-galactosamine

The enzyme from plants and animals also acts on N-acetyl-alpha-D-glucosamine 1-phosphate.

References

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  1. ^ Wang-Gillam A, Pastuszak I, Elbein AD (October 1998). "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc". The Journal of Biological Chemistry. 273 (42): 27055–7. doi:10.1074/jbc.273.42.27055. PMID 9765219.
  2. ^ Peneff C, Ferrari P, Charrier V, Taburet Y, Monnier C, Zamboni V, Winter J, Harnois M, Fassy F, Bourne Y (November 2001). "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture". The EMBO Journal. 20 (22): 6191–202. doi:10.1093/emboj/20.22.6191. PMC 125729. PMID 11707391.
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