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2-phospho-L-lactate transferase

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2-phospho-L-lactate transferase
Identifiers
EC no.2.7.8.28
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2-phospho-L-lactate transferase (EC 2.7.8.28, LPPG:Fo 2-phospho-L-lactate transferase, LPPG:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase, MJ1256, lactyl-2-diphospho-(5')guanosine:Fo 2-phospho-L-lactate transferase, CofD) is an enzyme with systematic name (2S)-lactyl-2-diphospho-5'-guanosine:7,8-didemethyl-8-hydroxy-5-deazariboflavin 2-phospho-L-lactate transferase.[1][2] This enzyme catalyses the following chemical reaction

(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin GMP + coenzyme F420-0

This enzyme is involved in the biosynthesis of coenzyme F420.

References

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  1. ^ Graupner M, Xu H, White RH (March 2002). "Characterization of the 2-phospho-L-lactate transferase enzyme involved in coenzyme F(420) biosynthesis in Methanococcus jannaschii". Biochemistry. 41 (11): 3754–61. doi:10.1021/bi011937v. PMID 11888293.
  2. ^ Forouhar F, Abashidze M, Xu H, Grochowski LL, Seetharaman J, Hussain M, Kuzin A, Chen Y, Zhou W, Xiao R, Acton TB, Montelione GT, Galinier A, White RH, Tong L (April 2008). "Molecular insights into the biosynthesis of the F420 coenzyme". The Journal of Biological Chemistry. 283 (17): 11832–40. doi:10.1074/jbc.m710352200. PMC 2431047. PMID 18252724.
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