In the beginning of the story, it is shown that the Germa Kingdom had managed to escape from Totto Land. Following this, Vinsmoke Judge and two of his children, Reiju and Ichiji are seen looking over a balcony, with Judge himself sighing.
However, back at Chocolat Town, two silhouettes appear and scare away the townsfolk, except for Choco Police, though he is surprised by their presence. Brûlée, who was with a still recovering Cracker, learns of this and states her belief that Vinsmoke Reiju and Ichiji have returned to rescue the other Vinsmokes while preparing to travel back there via mirror. But while this is happening, the book that the Vinsmoke brothers were trapped in suddenly catches on fire, freeing them. Ichiji and Reiju also burst through the wall and defeat the Charlotte siblings in order to rescue their own. Having reunited, the Vinsmokes then walk out as the facility goes up in flames.
As she continues to walk with her brothers, Reiju suspects someone else is around the corridor, who is in fact Caesar Clown, who failed to escape Whole Cake Island. Suddenly, both Oven and Katakuri appear and attack the Vinsmokes, but Caesar moves in and shrouds everyone with a hallucinatory gas. He then begs for the Vinsmokes to take him with them while the Charlotte brothers inadvertently fight each other due to the effect of the gas they were in. The Vinsmokes apparently agree to this and they all fly away from the fallen castle together.
The Vinsmoke siblings return to the Germa Kingdom along with Caesar. When they return, though, Caesar and Judge start fighting, and as they fought, they reminiscence their earlier days in MADS. As it turns out, MADS was supposedly a charitable lab dedicated to peace and was sponsored by Lu Feld. It was led by Dr. Vegapunk himself and also consisted of Caesar, Judge, Queen and an unknown woman. However, Caesar, Queen and Judge focused their efforts into creating weapons of mass destruction and carnage, with Caesar having created what could possibly be an artificial Devil Fruit. Unfortunately for them, the world was far more interested in Vegapunk's peaceful inventions, such as an artificial breed of flower that grew in gunpowder, which he received an award for. Ever since then, the three evil men began getting into fights between each other over who would be the second-best scientist of the organization, which apparently lasted for years, while Vegapunk is granted an audience with the Five Elders in Mary Geoise.
In the present, Caesar and Judge stop fighting after simultaneously coming to the conclusion that it was actually Vegapunk who got in their way of their progress. Thus, they decide to bury their grudge and form a new group called "NEO MADS" as a successor to the original MADS. The Germa soldiers celebrate the founding of this new organization while Ichiji and Reiju leave in a huff.
"Escape Whole Cake Island!!"
"Judge sighs"
"Niji & Yonji are held captive in Chocolat Town on Cacao Island"
"A creature beyond the power of science"
"This is for bullying Sanji-san! "Pudding Punch"!"
"Take Niji and Yonji to Whole Cake Island"
"Arrived at Whole Cake Island!"
"Mama's away on her trip. Begin the experiments!!"
"Two intruders in Pudding's home, Chocolat Town!!"
"I think Germa's come to Chocolat Town!!"
"Why?! The book in the lab burned up, freeing the brothers!!"
"Ichiji and Reiju show up"
"Germa's escape"
"The scientist who failed to escape"
"Katakuri and Oven arrive!!"
"Caesar's poison gas attack!!"
"Take me with you!! Get me outta here!!"
"Caesar's hallucination gas!!"
"Escape!! A successful rescue of Niji and Yonji!!"
"Meanwhile, in Chocolat Town, Cacao Island"
"Pudding's been abducted!!"
"Blackbeard Pirates, Kuzan and Augur"
"Germa returns, with added bonus"
"What's your name again?! Judge vs. Caesar!!"
"MADS, the group to which they once belonged"
"Loan Shark King Lu Feld's charitable research lab for peace, MADS"
"Promising scientists, brought together for the sake of mankind and the world"
"Mass-produced weapons of slaughter"
"Winner of the Ibel Peace Prize for 'GP Flowers' that bloom out of gunpowder"
"Three bitter rivals in the perpetual war to be No. 2"
"The Genius Scientist gets an audience with the Five Elders"
"Actually, I think our real problem is Vegapunk"
"The formation of NEO MADS!!"