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Notch signalling drives synovial fibroblast identity and arthritis pathology
NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.
- Kevin Wei
- , Ilya Korsunsky
- & Michael B. Brenner
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Letter |
Locally renewing resident synovial macrophages provide a protective barrier for the joint
Analysis of macrophage subsets within joints reveals a population of CX3CR1+ tissue-resident macrophages that form a tight-junction-mediated barrier at the synovial lining, protecting the joint from the invasion of inflammatory cells.
- Stephan Culemann
- , Anika Grüneboom
- & Gerhard Krönke
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Letter |
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
The authors identify in patients with rheumatoid arthritis a pathogenic subset of CD4+ T cells that augments B cell responses within inflamed tissues.
- Deepak A. Rao
- , Michael F. Gurish
- & Michael B. Brenner
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News |
High hopes for arthritis drugs
Race is on to develop treatments that inhibit signalling proteins.
- Heidi Ledford
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Letter |
IκBβ acts to inhibit and activate gene expression during the inflammatory response
Nuclear hypophosphorylated IκBβ is shown to bind p65:c-Rel dimers and maintain prolonged expression of TNF-α in response to stimulation by lipopolysaccharide.
- Ping Rao
- , Mathew S. Hayden
- & Sankar Ghosh
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes