Outlook |
Featured
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News |
Fruitfly genome mapped in three dimensions
The highest-resolution map of chromosome interactions in metazoans so far marks a new era of ‘3D genetics’.
- Rebecca Hill
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News |
Europe to map the human epigenome
DNA-modification studies get a multi-million euro boost.
- Alison Abbott
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Article |
The landscape of recombination in African Americans
- Anjali G. Hinch
- , Arti Tandon
- & Simon R. Myers
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Letter |
Genome-wide analysis reveals novel molecular features of mouse recombination hotspots
- Fatima Smagulova
- , Ivan V. Gregoretti
- & Galina V. Petukhova
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Article |
Mapping and analysis of chromatin state dynamics in nine human cell types
- Jason Ernst
- , Pouya Kheradpour
- & Bradley E. Bernstein
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Letter |
A cis-regulatory map of the Drosophila genome
As part of the modENCODE initiative, which aims to characterize functional DNA elements in D. melanogaster and C. elegans, this study created a map of the regulatory part of the fruitfly genome. On the basis of the developmental dynamics of chromatin modifications, polymerase and transcription factor occupancy this work defines a vast array of putative regulatory elements, such as enhancers, promoters, insulators and silencers. This resource represents the first attempt at a comprehensive annotation of cis-regulatory elements in a metazoan genome.
- Nicolas Nègre
- , Christopher D. Brown
- & Kevin P. White
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Article |
Mapping copy number variation by population-scale genome sequencing
Harnessing information from whole genome sequencing in 185 individuals, this study generates a high-resolution map of copy number variants. Nucleotide resolution of the map facilitates analysis of structural variant distribution and identification of the mechanisms of their origin. The study provides a resource for sequence-based association studies.
- Ryan E. Mills
- , Klaudia Walter
- & Jan O. Korbel
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Research Highlights |
Genetics: Where pain lives
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Letter |
Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition
Birds and mammals have distinct sex chromosomes: in birds, males are ZZ and females ZW; in mammals, males are XY and females XX. By sequencing the chicken Z chromosome and comparing it with the human X chromosome, these authors overturn the currently held view that these chromosomes have diverged little from their autosomal progenitors. The Z and X chromosomes seem to have followed convergent evolutionary trajectories, despite evolving with opposite systems of heterogamety.
- Daniel W. Bellott
- , Helen Skaletsky
- & David C. Page