Featured
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Article |
Methotrexate recognition by the human reduced folate carrier SLC19A1
Cryo-EM structures provide insight into how the antifolate methotrexate, a chemotherapy drug, is recognized by the reduced folate carrier.
- Nicholas J. Wright
- , Justin G. Fedor
- & Seok-Yong Lee
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Article
| Open AccessBoron clusters as broadband membrane carriers
The superchaotropic nature of globular boron cluster anions enables direct passage of a wide range of molecules across lipid membranes.
- Andrea Barba-Bon
- , Giulia Salluce
- & Werner M. Nau
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Article |
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
In a cynomolgus macaque model, CRISPR base editors delivered in lipid nanoparticles are shown to efficiently and stably knock down PCSK9 in the liver to reduce levels of PCSK9 and low-density lipoprotein cholesterol in the blood.
- Kiran Musunuru
- , Alexandra C. Chadwick
- & Sekar Kathiresan
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Letter |
Molecular machines open cell membranes
Rotary molecular machines, activated by ultraviolet light, are able to perturb and drill into cell membranes in a controllable manner, and more efficiently than those exhibiting flip-flopping or random motion.
- Víctor García-López
- , Fang Chen
- & James M. Tour
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Letter |
Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
The development of a nanoparticle RNA vaccine is reported that preferentially targets dendritic cells after systemic administration, and is shown to provide durable interferon-α-dependent antigen-specific immunity in mouse tumour models; initial results in advanced melanoma patients indicate potential efficacy in humans.
- Lena M. Kranz
- , Mustafa Diken
- & Ugur Sahin
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Letter |
MicroRNA silencing for cancer therapy targeted to the tumour microenvironment
A novel anti-microRNA delivery platform that targets the acidic tumour microenvironment, in which a chosen anti-miRNA is coupled to a peptide that can transport the anti-miRNA across cell membranes specifically in an acidic environment.
- Christopher J. Cheng
- , Raman Bahal
- & Frank J. Slack
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Outlook |
Nanotechnology: Deliver on a promise
Effective treatment of cancer requires getting the drugs precisely to the target. Enter the nanoparticle.
- Jessica Wright
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Outlook |
Nanotechnology: Carrying drugs
Traditional chemotherapies can be toxic but nano-sized carriers can keep them out of healthy tissue and take old drugs to new places.
- Katherine Bourzac
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News & Views |
Liposomes derived from molecular vases
Liposomes are ubiquitous components of skin moisturizers and other personal-care products. Modified liposomes prepared from receptor-like molecules open up fresh opportunities for therapeutic and industrial applications.
- Cyrus R. Safinya
- & Kai K. Ewert
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Research Highlights |
Nanoparticles home in to clear clots
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Research Highlights |
On-demand drug release
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Research Highlights |
Six-faced particles
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News |
Nanoparticles hit tumours with one-two punch
Using scout particles to pave the way makes drug delivery more effective.
- Corie Lok
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News |
Diamonds deliver on cancer treatment
Carbon nanoparticles promise multifaceted benefits in transporting drugs.
- Marian Turner
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Research Highlights |
Lights on for drug delivery
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News |
Pliable particles open door to drug delivery
Hydrogel mimics of red blood cells can sneak through tight spots.
- Tiffany O'Callaghan
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Research Highlights |
Materials science: Magnetic gel delivers drugs
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Research Highlights |
Chemistry: Tiny molecular 'water bottle'
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Technology Feature |
Homing in on delivery
The scientific community now seems convinced that small RNAs will become therapies, if new tools can help these large molecules to make it safely into cells. Monya Baker reports.
- Monya Baker
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Research Highlights |
Biomaterials: Squishy particles