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Bipolar disorder is a mood disorder that includes at least one manic episode – characterized by elevated or agitated mood and often reduced need for sleep – accompanied by episodes of major depression.
In this study the authors investigate whether prepulse inhibition, measured in late pregnancy, could predict depressive symptom status at 6 weeks postpartum.
Human and animal studies reveal a neurobiological pathway that connects polygenic risks and behavioural changes that are shared between schizophrenia and bipolar mood disorder.