Extended Data Fig. 8: XBB.1.5 monovalent booster increases serum binding to multiple neutralizing epitopes on the XBB.1.5 spike protein.
From: Imprinting of serum neutralizing antibodies by Wuhan-1 mRNA vaccines
a, Schematic of the mAb competition assay (competing serum antibody, red; non-competing serum antibody, salmon; fluorescence-labeled mAb, blue). b, Percent binding of the indicated mAbs competed by serially diluted pre- and post-boost serum of XBB.1.5 monovalent vaccine boosted individuals described in Fig. 4 to XBB.1.5 spike protein. Two naïve sera (black curves, no SARS-CoV-2 infection or vaccination history) were included as control. c, Competition titre of pre- and post-boost sera that inhibits 50% binding of the indicated mAbs (numbers on the top indicate GMT fold increases), derived from b.