Extended Data Fig. 5: Microbiota dependent regulation of CTLA-4.
From: CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation
a, Flow cytometry plots with graph of CTLA-4+ ILC1s and CTLA-4+ NK cells frequencies in large intestine lamina propria of conventional SPF, germ-free (GF) and SPF Rag1−/− mice treated with antibiotics (ABX) (n = 8 mice). b, Graph of CTLA-4+ ILC1s and CTLA-4+ NK cells frequencies in small intestine lamina propria of conventional SPF, germ-free and SPF mice treated with antibiotics on Rag1−/− background (n = 8 mice). c, Graph of CTLA-4+ ILC1s, CTLA-4+ NK cells and CTLA-4+ γδ T cells frequencies in small intestine lamina propria of SPF mice ex vivo stimulated with indicated cytokines (n = 4 mice). Data in a-b were pooled from two independent experiments and shown as Mean ± s.d. Data in c are representative of two or three independent experiments with similar results and shown as Mean ± s.d. The statistics in a-c were calculated by one-way ANOVA with Dunnett’s multiple comparisons.