Extended Data Fig. 8: In vivo CIM053-SG3376 mediated selective tumour eradication with preserved haematopoiesis of edited cells.
From: Selective haematological cancer eradication with preserved haematopoiesis
a, Weight curves depicting weight loss relative to weight at start of NBSGW mice humanised with control (sgNTC) or shielded (sg49.3) HSPCs, followed by MOLM-14 tumour xenograft injection. The mice were subsequently subjected to either saline treatment or CIM053-SG3376 treatment. b, Quantification of MOLM-14 cells (%BC8+mCD45−mCherry+) in the spleen and blood of all mice from (a). c, Quantification of non-tumour human cells (%BC8+mCD45−mCherry−) in the spleen and blood of all mice from (a). (In (a-c), 3-4 mice in saline groups and 10 mice in CIM053-SG3376 treated groups, plotting mean values +/− SD). (Ordinary two-way ANOVA tests (alpha 0.05) were employed to assess statistical difference between groups).