Extended Data Fig. 7
From: Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer
(a) Cell lines derived from RMC-7977 resistant KPC tumors and (b) human PDAC cell lines treated with DMSO, RMC-7977, IAG933 or combinations. (Top rows) Viability levels of cell lines treated with a range of RMC-7977 concentrations in combination with indicated concentration of IAG933. Line colors correspond to IAG933 concentration. Data points in (a) represent the mean of 3-4 biological replicates normalized to DMSO control. Error bars indicate ±s.d. (Bottom rows) The dose–response matrices show combination synergy based on cell viability at different dose pairs. Each cell line in (b) represents one biological replicate (n = 8).