Extended Data Fig. 8: The tumour heterogeneity in the mini-colon is relatable to the human context.
From: Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo
a, Expression distribution of intrinsic consensus molecular subtype (iCMS) signatures across tumour cells in the mini-colon. Cell-type labels can be found in Fig. 3d. Exp, expression. b, Fraction of cells within each tumour clone in the mini-colon classified in each iCMS group. c, Survival of CRC patients from the TCGA database according to the expression of the indicated tumour clone-specific markers. The logrank test P value is indicated (n = 375 patients). d, Presence of cancer cells in lymph nodes from CRC patients from the TCGA database according to the expression of the indicated tumour clone-specific markers. ***P = 2.714·10−5 (two-sided Wilcoxon test; n = 375 patients). e, Lymph node staging in CRC patients from the TCGA database according to the expression of the indicated tumour clone-specific markers. *P = 0.0222; **P = 4.923·10−3 (two-sided Chi-squared test; n = 375 patients).