Extended Data Fig. 6: Mini-colons comprise a complex cellular ecosystem.
From: Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo
a, Expression distribution of cell–type-specific markers across mini-colon cells. Cell-type labels can be found in Fig. 3b. b, Examples of single-cell RNA reads capturing exon-exon junctions that reveal the expected oncogenic recombination in Apc. c, Examples of single-cell RNA reads capturing exon-exon junctions that reveal the expected oncogenic recombination in Trp53. d, Unsupervised UMAP clustering of the main cell types found in each of the healthy and tumour clonal populations found within the mini-colon. Tumour clones carry the “CRC” label. UMAP structure corresponds to the one shown in Fig. 3b.