Extended Data Fig. 4: Sequence alignment of TAS2R family and Gα proteins.
From: Bitter taste receptor activation by cholesterol and an intracellular tastant
a, The residues of TAS2R14 mentioned throughout the text are labeled as generic residue numbering. The black squares, stars, and circles indicate the residues involved in the interactions with cholesterol, cmpd28.1, and the α5 helices of Gαi1 and Gαgust. b, Sequence alignment of α5 helix of Gα subunits. Labeled residues interact with TAS2R14. The sequence was aligned using GPCR generic residue numbers based on GPCRdb (https://gpcrdb.org) (a,b).