Extended Data Fig. 2: RNA structure prediction.
From: On the genetic basis of tail-loss evolution in humans and apes
a, Predicted RNA secondary structure of the TBXT exon5-to-exon7 sequence using the RNAfold algorithm of the ViennaRNA package35. The paired AluY-AluSx1 region was highlighted. b, Mountain plot of the RNA secondary structure prediction, showing the ‘height’ in predicted secondary structure across the nucleotide positions. Height was computed as the number of base pairs enclosing the base at a given position. Overall, the AluSx1 and AluY regions were predicted to form helices with high probability (low entropy).