Extended Data Fig. 8: Exon6 deletion of Tbxt may lead to neural tube defects in mouse.
From: On the genetic basis of tail-loss evolution in humans and apes
a, Analyzing E11.5 TbxtΔexon6/Δexon6 mouse embryos obtained through intercrossing TbxtΔexon6/+ mice. TbxtΔexon6/Δexon6 embryos either developed neural tube closure defects (middle) that died at birth or arrested at approximately stage E9 during development (right). Red and black dashed lines mark the embryonic tail regions and limb buds, respectively. Green arrowheads indicate malformed spinal cord regions. b-c, Both TbxtΔexon6/Δexon6 (b) and TbxtΔexon6/+ (c) neonatal mice may present neural tube closure defects during embryonic development. The presented embryos were the only two cases found in this study that died after birth with neural tube closure defects.