Extended Data Fig. 8: Comparison of MICs of different compounds against methicillin-susceptible and methicillin-resistant S. aureus, and eradication of kanamycin persisters by treatment with compounds 1 and 2.
From: Discovery of a structural class of antibiotics with explainable deep learning
a, MICs of various antibiotics against S. aureus RN4220 (black) and S. aureus USA300 (blue) on a log scale. Bars show the mean of two biological replicates (individual points). b, Survival curves of B. subtilis 168 after combination treatment with kanamycin and compounds 1 and 2, respectively, as determined by plating and CFU counting. Initial CFU values are ~107. Each point is representative of the mean of two biological replicates. Cultures treated with kanamycin in addition to compounds 1 and 2 were eradicated after 24 h (CFU/mL = 0), and these values were truncated to a log survival value of −7 on this plot.