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TSPAN4

From Wikipedia, the free encyclopedia
TSPAN4
Identifiers
AliasesTSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDsOMIM: 602644; MGI: 1928097; HomoloGene: 2453; GeneCards: TSPAN4; OMA:TSPAN4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252588
NM_053082

RefSeq (protein)
Location (UCSC)Chr 11: 0.84 – 0.87 MbChr 7: 141.06 – 141.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.[5][6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]

Interactions

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TSPAN4 has been shown to interact with CD9,[5] ITGA6,[5] CD29,[5] CD49c[5] and CD81.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214063Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025511Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c d e f Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
  6. ^ a b "Entrez Gene: TSPAN4 tetraspanin 4".

Further reading

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