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Sterigmatocystin 8-O-methyltransferase

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sterigmatocystin 7-O-methyltransferase
Identifiers
EC no.2.1.1.110
CAS no.116958-29-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a sterigmatocystin 8-O-methyltransferase (EC 2.1.1.110) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + sterigmatocystin S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin

Thus, the two substrates of this enzyme are S-adenosyl methionine and sterigmatocystin, whereas its two products are S-adenosylhomocysteine and 8-O-methylsterigmatocystin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:sterigmatocystin 8-O-methyltransferase. Other names in common use include sterigmatocystin methyltransferase, O-methyltransferase II, sterigmatocystin 7-O-methyltransferase (incorrect), S-adenosyl-L-methionine:sterigmatocystin 7-O-methyltransferase, and (incorrect).

References

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  • Bhatnagar D, McCormick SP, Lee LS, Hill RA (1987). "Identification of O-methylsterigmatocystin as an aflatoxin B1 and G1 precursor in Aspergillus parasiticus". Appl. Environ. Microbiol. 53 (5): 1028–33. PMC 203804. PMID 3111363.
  • Yabe K, Ando Y, Hashimoto J, Hamasaki T (1989). "Two distinct O-methyltransferases in aflatoxin biosynthesis". Appl. Environ. Microbiol. 55 (9): 2172–7. PMC 203052. PMID 2802602.