Jump to content

Proteasome ATPase

From Wikipedia, the free encyclopedia
Proteasome ATPase
Identifiers
EC no.3.6.4.8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a proteasome ATPase (EC 3.6.4.8) is an enzyme that catalyzes the chemical reaction

ATP + H2O ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (polypeptide-degrading).

References

[edit]
  • Rivett AJ, Mason GG, Murray RZ, Reidlinger J (1997). "Regulation of proteasome structure and function". Mol. Biol. Rep. 24 (1–2): 99–102. doi:10.1023/A:1006814306401. PMID 9228289.
  • Mason GG, Murray RZ, Pappin D, Rivett AJ (1998). "Phosphorylation of ATPase subunits of the 26S proteasome". FEBS Lett. 430 (3): 269–74. doi:10.1016/S0014-5793(98)00676-0. PMID 9688553.