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O-phospho-L-seryl-tRNA:Cys-tRNA synthase

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O-phospho-L-seryl-tRNA:Cys-tRNA synthase
Identifiers
EC no.2.5.1.73
CAS no.1239229-21-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

O-phospho-L-seryl-tRNA:Cys-tRNA synthase (EC 2.5.1.73, SepCysS, Sep-tRNA:Cys-tRNA synthase) is an enzyme with systematic name O-phospho-L-seryl-tRNACys:hydrogen sulfide 2-aminopropanoate transferase.[1][2][3] This enzyme catalyses the following chemical reaction

O-phospho-L-seryl-tRNACys + sulfide L-cysteinyl-tRNACys + phosphate

References

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  1. ^ Fukunaga R, Yokoyama S (June 2007). "Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus". Journal of Molecular Biology. 370 (1): 128–41. doi:10.1016/j.jmb.2007.04.050. PMID 17512006.
  2. ^ Hauenstein SI, Perona JJ (August 2008). "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". The Journal of Biological Chemistry. 283 (32): 22007–17. doi:10.1074/jbc.M801839200. PMC 2494925. PMID 18559341.
  3. ^ Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (December 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proceedings of the National Academy of Sciences of the United States of America. 103 (50): 18923–7. Bibcode:2006PNAS..10318923Y. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.
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