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O-demethylpuromycin O-methyltransferase

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O-demethylpuromycin O-methyltransferase
Identifiers
EC no.2.1.1.38
CAS no.37257-04-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an O-demethylpuromycin O-methyltransferase (EC 2.1.1.38) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + O-demethylpuromycin S-adenosyl-L-homocysteine + puromycin

Thus, the two substrates of this enzyme are S-adenosyl methionine and O-demethylpuromycin, whereas its two products are S-adenosylhomocysteine and puromycin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase. This enzyme is also called O-demethylpuromycin methyltransferase. This enzyme participates in puromycin biosynthesis.

References

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  • Rao MM, Rebello PF, Pogell BM (1969). "Biosynthesis of puromycin in Streptomyces alboniger. Enzymatic methylation of O-demethylpuromycin". J. Biol. Chem. 244 (1): 112–8. PMID 5773275.