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NCOA5

From Wikipedia, the free encyclopedia
NCOA5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNCOA5, CIA, bA465L10.6, nuclear receptor coactivator 5
External IDsOMIM: 616825; MGI: 2385165; HomoloGene: 32496; GeneCards: NCOA5; OMA:NCOA5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020967

NM_144892

RefSeq (protein)

NP_066018
NP_001335077
NP_001335078
NP_001335079
NP_001335080

NP_659141

Location (UCSC)n/aChr 2: 164.84 – 164.88 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.[4][5]

Function

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This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor Rev-ErbA beta. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.[4]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039804Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ a b "Entrez Gene: NCOA5 nuclear receptor coactivator 5".
  5. ^ Sauvé F, McBroom LD, Gallant J, Moraitis AN, Labrie F, Giguère V (January 2001). "CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant". Molecular and Cellular Biology. 21 (1): 343–53. doi:10.1128/MCB.21.1.343-353.2001. PMC 88807. PMID 11113208.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.