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GPIHBP1

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GPIHBP1
Identifiers
AliasesGPIHBP1, GPI-HBP1, HYPL1D, glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
External IDsOMIM: 612757; MGI: 1915703; HomoloGene: 18651; GeneCards: GPIHBP1; OMA:GPIHBP1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178172
NM_001301772

NM_026730
NM_001347039
NM_001361294

RefSeq (protein)

NP_001288701
NP_835466

NP_001333968
NP_081006
NP_001348223

Location (UCSC)Chr 8: 143.21 – 143.22 MbChr 15: 75.47 – 75.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPI-HBP1) also known as high density lipoprotein-binding protein 1 is a protein that in humans is encoded by the GPIHBP1 gene.[5]

Function

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Dietary fats are packaged by intestine into triglyceride-rich lipoproteins called chylomicrons. The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LPL) along the luminal surface of capillaries, mainly in heart, skeletal muscle, and adipose tissue. GPIHBP1 is a capillary endothelial cell protein that provides a platform for LPL-mediated processing of chylomicrons.[5][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000277494Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022579Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1".
  6. ^ Beigneux AP, Davies BS, Gin P, Weinstein MM, Farber E, Qiao X, Peale F, Bunting S, Walzem RL, Wong JS, Blaner WS, Ding ZM, Melford K, Wongsiriroj N, Shu X, de Sauvage F, Ryan RO, Fong LG, Bensadoun A, Young SG (April 2007). "Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons". Cell Metab. 5 (4): 279–91. doi:10.1016/j.cmet.2007.02.002. PMC 1913910. PMID 17403372.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.