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Friedelin synthase

From Wikipedia, the free encyclopedia
Friedelin synthase
Identifiers
EC no.5.4.99.50
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Friedelin synthase (EC 5.4.99.50) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, friedelin-forming).[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene friedelin

The enzyme from Kalanchoe daigremontiana also gives traces of other triterpenoids.

References

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  1. ^ Wang Z, Yeats T, Han H, Jetter R (September 2010). "Cloning and characterization of oxidosqualene cyclases from Kalanchoe daigremontiana: enzymes catalyzing up to 10 rearrangement steps yielding friedelin and other triterpenoids". The Journal of Biological Chemistry. 285 (39): 29703–12. doi:10.1074/jbc.m109.098871. PMC 2943309. PMID 20610397.
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