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Cobalt-factor II C20-methyltransferase

From Wikipedia, the free encyclopedia
cobalt-factor II C20-methyltransferase
Identifiers
EC no.2.1.1.151
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a cobalt-factor II C20-methyltransferase (EC 2.1.1.151) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + cobalt-factor II S-adenosyl-L-homocysteine + cobalt-factor III

The two substrates of this enzyme are S-adenosyl methionine and cobalt-factor II; its two products are S-adenosylhomocysteine and cobalt-factor III.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:cobalt-factor-II C20-methyltransferase. This enzyme is also called CbiL. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.

See also

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References

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  • Spencer P, Stolowich NJ, Sumner LW, Scott AI (1998). "Definition of the redox states of cobalt-precorrinoids: investigation of the substrate and redox specificity of CbiL from Salmonella typhimurium". Biochemistry. 37 (42): 14917–27. doi:10.1021/bi981366f. PMID 9778368.