Jump to content

Aminocandin

From Wikipedia, the free encyclopedia
Aminocandin
Clinical data
Other namesIP-960, HMR-3270
ATC code
  • none
Identifiers
  • 1-[4-[(2-aminoethyl)amino]-N2-[(4'-octyloxy)[1,1'-biohenyl]-4-yl]carbonyl]-L-ornithine]-4-[4-(4-hydroxyphenyl)-L-threonine]-5-L-serine-echinocandin B
CAS Number
PubChem CID
ChemSpider
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC56H79N9O13
Molar mass1086.298 g·mol−1
3D model (JSmol)
  • CCCCCCCCOc1ccc(cc1)c2ccc(cc2)C(=O)NC3CC(CNC(=O)[C@@H]4[C@H]([C@H](CN4C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]5C[C@H](CN5C(=O)[C@@H](NC3=O)[C@@H](C)O)O)[C@@H](Cc6ccccc6)O)CO)C)O)NCCN
  • InChI=1S/C56H79N9O13/c1-4-5-6-7-8-12-25-78-41-21-19-37(20-22-41)36-15-17-38(18-16-36)50(71)60-42-27-39(58-24-23-57)29-59-54(75)48-49(70)33(2)30-65(48)55(76)43(32-66)61-53(74)47(45(69)26-35-13-10-9-11-14-35)63-52(73)44-28-40(68)31-64(44)56(77)46(34(3)67)62-51(42)72/h9-11,13-22,33-34,39-40,42-49,58,66-70H,4-8,12,23-32,57H2,1-3H3,(H,59,75)(H,60,71)(H,61,74)(H,62,72)(H,63,73)/t33-,34+,39?,40+,42?,43+,44-,45+,46-,47-,48-,49-/m0/s1
  • Key:JYBUOENGZWTZGU-JZCGONIASA-N
 ☒NcheckY (what is this?)  (verify)

Aminocandin is an echinocandin antifungal. It works by targeting the glucan in fungal cell walls.[1][2]

References

[edit]
  1. ^ Andes D, Marchillo K, Lowther J, Bryskier A, Stamstad T, Conklin R (April 2003). "In vivo pharmacodynamics of HMR 3270, a glucan synthase inhibitor, in a murine candidiasis model". Antimicrobial Agents and Chemotherapy. 47 (4): 1187–92. doi:10.1128/aac.47.4.1187-1192.2003. PMC 152480. PMID 12654645.
  2. ^ Brzankalski GE, Najvar LK, Wiederhold NP, Bocanegra R, Fothergill AW, Rinaldi MG, et al. (November 2008). "Evaluation of aminocandin and caspofungin against Candida glabrata including isolates with reduced caspofungin susceptibility". The Journal of Antimicrobial Chemotherapy. 62 (5): 1094–100. doi:10.1093/jac/dkn304. PMC 2721694. PMID 18658194.
[edit]