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Acyl-(acyl-carrier-protein)—phospholipid O-acyltransferase

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acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase
Identifiers
EC no.2.3.1.40
CAS no.37257-18-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, an acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase (EC 2.3.1.40) is an enzyme that catalyzes the chemical reaction

acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine [acyl-carrier protein] + O-(1,2-diacyl-sn-glycero-3-phospho)ethanolamine

Thus, the two substrates of this enzyme are acyl-acyl-carrier protein and O-(2-acyl-sn-glycero-3-phospho)ethanolamine, whereas its two products are acyl-carrier protein and O-(1,2-diacyl-sn-glycero-3-phospho)ethanolamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-[acyl-carrier protein]:O-(2-acyl-sn-glycero-3-phospho)ethanolamine O-acyltransferase. Other names in common use include acyl-[acyl-carrier, protein]:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine, and O-acyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

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  • Taylor SS, Heath EC (1969). "The incorporation of beta-hydroxy fatty acids into a phospholipid of Escherichia coli B". J. Biol. Chem. 244 (24): 6605–16. PMID 4902888.