Doors that require two keys (Vault and Dice Room) only require one bomb to open.
Mega Chests require multiple explosions in order to be opened, just as when using keys.
Synergies[ | ]
Notched Axe: Allows the Notched Axe to open locked chests and doors. The opening of chests does not use durability; however, when opening locked doors, only every other door does not use durability for the first four doors opened on the current floor. If Isaac uses the axe's durability or puts away the axe, the other door uses durability to open.
Options?: Bombing any chest spawned by Options?, including the ones not requiring keys, allows picking up the contents of the chest without the other reward disappearing, unless the empty chest is touched. This can be easily avoided by simply exiting and reentering the room.