Reviews & Analysis

This PrimeView highlights the pathophysiological mechanisms of von Willebrand disease, and summarizes the epidemiology, diagnosis, management and quality of life of this disorder. It accompanies the Primer article on this topic by Seidizadeh et al.

von Willebrand disease (VWD) is the most common inherited bleeding disorder. VWD is characterized by defects in von Willebrand factor, the largest plasma glycoprotein in humans. In this Primer, Seidizadeh and colleagues discuss the epidemiology, mechanisms, diagnosis and treatments for VWD.

This PrimeView highlights the diagnosis of catatonia, and summarizes the epidemiology, mechanisms, management and future research directions for this disorder. It accompanies the Primer article on this topic by Hirjak et al.

Catatonia is a complex neuropsychiatric disorder characterized by diverse motor, affective and cognitive–behavioural signs. In this Primer, Hirjak and colleagues review the epidemiology, pathophysiology, diagnosis, management and quality of life of patients with this disorder.

This PrimeView highlights the pathophysiological mechanisms of biliary atresia, and summarizes the epidemiology, diagnosis and management of this disorder. It accompanies the Primer article on this topic by Tam et al.

Biliary atresia is a devastating paediatric inflammatory disease of the bile ducts that restricts flow of bile from the liver. In this Primer, Tam et al. summarize current research on biliary atresia, covering its epidemiology, mechanisms, diagnosis and management, quality of life, and future directions for research.

This PrimeView highlights the epidemiology, mechanisms, diagnosis, management and quality of life of patients with multiple myeloma.

Multiple myeloma is a haematological lymphoid malignancy involving tumoural plasma cells. In this Primer, Malard et al. discuss the epidemiology, mechanisms, diagnosis and treatments for multiple myeloma.

This PrimeView highlights the epidemiology of altitude illnesses, and summarizes the mechanisms, diagnosis and management of these conditions. It accompanies the Primer article on this topic by Gatterer et al.

Acute or chronic exposure to elevations above 2,500 m can lead to altitude illnesses, including acute mountain sickness, high-altitude cerebral or pulmonary oedema, and chronic mountain sickness. In this Primer, Gatterer et al. summarize the epidemiology and pathophysiology of these disorders, discuss diagnosis, prevention and treatment, and highlight areas for future research.

This PrimeView highlights the epidemiology, mechanisms, diagnosis, management and quality of life of patients with acute lymphoblastic leukaemia.

Acute lymphoblastic leukaemia (ALL) is a haematological malignancy characterized by the uncontrolled proliferation of immature lymphoid cells. In this Primer, Pagliaro et al. discuss the epidemiology, mechanisms, diagnosis and treatments of ALL.

This PrimeView highlights the epidemiology, mechanisms, diagnosis, management and quality of life of patients with trigeminal neuralgia, a chronic facial pain disorder.

In this Primer, Ashina et al. discuss the epidemiology, pathophysiology, diagnosis, management and quality of life of patients with trigeminal neuralgia, a chronic neuropathic facial pain disorder involving one or more branches of the trigeminal nerve that causes intense paroxysms of electric shock-like pain.

This PrimeView highlights the epidemiology, mechanisms, diagnosis, management and quality of life of patients with carpal tunnel syndrome.

Carpal tunnel syndrome (CTS) is one of the most common hand conditions caused by an increased pressure on the median nerve in the carpal tunnel in the wrist. In this Primer, Dahlin et al. review the epidemiology, pathophysiology, diagnosis, management and quality of life of people with CTS; they also highlight occupational risk factors for this condition.

This PrimeView highlights the epidemiology of paediatric hydrocephalus and accompanies the Primer article on this topic by Kahle and colleagues.

Paediatric hydrocephalus is the progressive distension of the cerebral ventricles in infancy or childhood. This Primer discusses the epidemiology, pathophysiology, diagnosis, screening and treatment of paediatric hydrocephalus in both high-income and low- and middle-income settings.

This Primeview highlights the management of glioma, and accompanies the Primer article on this topic by Weller et al.

This Primer by Weller and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of glioma in both adults and children.