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Directing risky traffic in B cells with TNIP1
TNIP1, a previously identified risk factor for autoimmunity, regulates mitochondrial autophagosomal trafficking. Missense mutations in TNIP1 disrupt this regulatory function, yielding a B cell-intrinsic predisposition for TLR7-mediated autoimmunity characterized by IgG4 autoantibodies and the expansion of age-associated B cells.
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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
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A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
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PD-L2 is a second ligand for PD-1 and inhibits T cell activation
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T cell dysfunction and therapeutic intervention in cancer