Zhao, Yang et al. used UK Biobank data to examine the role of lifestyle factors in depression. They conducted multiple analyses and estimated underlying mechanisms related to brain structure, immunometabolism and genetics.

The authors conducted a systematic review and individual participant data meta-analysis of 14 studies to evaluate psychological interventions for depression relapse prevention.

Using a large sample from the UK Biobank, the authors investigate the effects of dietary patterns on multiple aspects of brain health and mental health.

The authors conducted a systematic review and individual participant data meta-analysis of 14 studies to evaluate psychological interventions for depression relapse prevention.

Using a card gambling task paired with intracranial recordings and deep brain stimulation of the right subthalamic nucleus, the authors dissociate objective and subjective markers of risk taking and demonstrate the role of stimulation localization on risk-related behavior.

In this study, analyzing Czech national register-based data and using genome-wide Mendelian randomization, the authors report elevated risk for developing substance use, mood, anxiety and personality disorders in individuals with childhood-onset type 1 diabetes, and show that these associations are unlikely to be explicable by common underlying biological mechanisms.

In this cohort study, the authors find that depressive symptoms at the beginning of the pandemic may partially explain why women participants who had a COVID-19 episode were more likely than their male counterparts to report at least one post-COVID-19 persistent symptom seven to ten months later.

In this study, the authors use a combination of genetic methodologies to investigate the genetic associations between attention-deficit/hyperactivity disorder, cannabis use disorder and cannabis use.

Using deep brain stimulation of the habenula with implanted electrodes in patients with treatment-resistant depression, this study found a substantial reduction in depression scores at follow-up over multiple time points.

Mood dysfunction is more common in people with brain tumors than in those with other tumor types, but the reasons for this association are unclear. Using various methods for lesion–symptom mapping, we identified brain locations in patients with diffuse glioma that are related to severe depressive symptoms or an absence of depressive symptoms.

This Review explores the link between mood disorders and circadian disruptions, including social jet lag and shift work, and offers new perspectives for therapeutic development in future chronobiology research.

The authors report how the anatomical location of diffuse gliomas is related to the occurrence of severe depressive symptoms or the absence of depressive symptoms.